词条 | 5-MeO-DALT | ||||||||||||||||||||||||||||||||||||||||||||||
释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477224887 | IUPAC_name = N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-(prop-2-en-1-yl)prop-2-en-1-amine | image = 5-MeO-DALT.svg | width = 200px | tradename = | legal_UK = Class A | legal_status = Illegal in China, Japan, Singapore, Sweden, Florida and Louisiana | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 928822-98-4 | PubChem = 50878551 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 21106245 | C=17 | H=22 | N=2 | O=1 | molecular_weight = 270.375 g/mol | smiles = C=CCN(CCC1=CNC2=C1C=C(OC)C=C2)CC=C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H22N2O/c1-4-9-19(10-5-2)11-8-14-13-18-17-7-6-15(20-3)12-16(14)17/h4-7,12-13,18H,1-2,8-11H2,3H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HGRHWEAUHXYNNP-UHFFFAOYSA-N }} 5-MeO-DALT or N,N-di allyl-5-methoxy tryptamine is a psychedelic tryptamine first synthesized by Alexander Shulgin. ChemistryThe full name of the chemical is N-allyl-N-[2-(5-methoxy-1H-indol-3-yl)ethyl] prop-2-en-1- amine. It is related to the compounds 5-MeO-DPT and DALT. Pharmacology5-MeO-DALT binds to 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, α2A, α2B, α2C, H1, κ-opioid, σ1 and σ2 receptors with Ki values lower than 10μM and also acts as a DAT and SERT monoamine reuptake inhibitor.[1]
The metabolism and cytochrome P450 inhibition of 5-MeO-DALT has been described in scientific literature.[2][3] HistoryThe first material regarding the synthesis and effects of 5-MeO-DALT was sent from Alexander Shulgin to a research associate named Murple in May 2004, after which it was circulated online. In June 2004 5-MeO-DALT became available from internet research chemical vendors after being synthesized by commercial laboratories in China. In August 2004 the synthesis and effects of 5-MeO-DALT were published by Erowid.[4] DosageDoses ranging from 12–20 mg were tested by Alexander Shulgin's research group.[5] Side effectsThere is no published literature on the toxicity of 5-MeO-DALT. Legal StatusChinaAs of October 2015 5-MeO-DALT is a controlled substance in China.[6] Japan5-MeO-DALT became a controlled substance in Japan from April 2007, by amendment to the Pharmaceutical Affairs Law.[7] United Kingdom5-MeO-DALT became a Class A drug in the UK on January 7th 2015 after an update to the tryptamine blanket ban. Singapore5-MeO-DALT is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[8] SwedenSveriges riksdag added 5-MeO-DALT to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 5-MeO-DALT N-allyl-N-[2-(5-metoxi-1H-indol-3-yl)etyl]-prop-2-en-1-amin.[9]United States5-MeO-DALT is not scheduled at the federal level in the United States,[10] but it is likely that it could be considered an analog of 5-Meo-DiPT or another tryptamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act. Florida5-MeO-DALT is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[11] Louisiana5-MeO-DALT is a Schedule I controlled substance in the state of Louisiana making it illegal to buy, sell, or possess in Louisiana.[12] Notes1. ^{{cite journal | url=http://www.sciencedirect.com/science/article/pii/S0960894X1530367X | title=Receptor binding profiles and quantitative structure-affinity relationships of some 5–substituted-N,N-diallyltryptamines | author=Nicholas V. Cozzi | author2=Paul F. Daley | journal=Bioorganic & Medicinal Chemistry Letters | volume=26 | issue=3 | pages=959–964 | year=December 2015 | doi=10.1016/j.bmcl.2015.12.053| pmid=26739781 }} 2. ^{{cite journal | title=Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC–MS, LC–MS n , and LC–HR–MS–MS | author=Julian A. Michely | author2=Andreas G. Helfer | author3=Simon D. Brandt| author4=Markus R. Meyer | author5=Hans H. Maurer | journal=Analytical and Bioanalytical Chemistry |date=August 2015 | doi=10.1007/s00216-015-8955-0 | pmid=26297461 | volume=407 |issue = 25| pages=7831–42| url=http://researchonline.ljmu.ac.uk/3406/1/ABC-01148-2015.R1.pdf }} 3. ^{{cite journal | url=http://www.sciencedirect.com/science/article/pii/S0378427415301107 | title=Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class | author=Julia Dinger | author2=Campbell Woods | author3=Simon D. Brandt| author4=Markus R. Meyer | author5=Hans H. Maurer | journal=Toxicology Letters | date=January 2016 | volume=241 | pages=82–94 | doi=10.1016/j.toxlet.2015.11.013 | pmid=26599973}} 4. ^{{cite web | url=https://www.vice.com/read/the-last-interview-with-alexander-shulgin-423-v17n5 | title=The Last Interview With Alexander Shulgin | publisher=Vice | date=2 May 2010 | accessdate=3 September 2015 | author=Hamilton Morris | author2=Ash Smith}} 5. ^{{cite web | url=https://www.youtube.com/watch?v=ijXkk4OLDpk | title=Sasha Shulgin - 5-MeO-DALT, 2C-B-FLY & 5-EtOs | accessdate=3 September 2015}} 6. ^{{cite web | url=http://www.sfda.gov.cn/WS01/CL0056/130753.html | title=关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | publisher=China Food and Drug Administration | date=27 September 2015 | language=Chinese | accessdate=1 October 2015}} 7. ^{{ cite web | url = http://www.mhlw.go.jp/houdou/2007/08/h0810-3.html | title = 厚生労働省:平成18年度無承認無許可医薬品等買上調査の結果について | language=Japanese | accessdate =24 July 2015 }} 8. ^{{cite web | url=http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx | title=CNB NEWS RELEASE | publisher=Central Narcotics Bureau (CNB) | date=30 April 2015 | accessdate=24 July 2015}} 9. ^{{cite web | url=https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf | title=Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika | date=20 April 2012 | accessdate=3 September 2015 | language=Swedish | author=Generaldirektör Christina Rångemark Åkerman}} 10. ^§1308.11 Schedule I. 11. ^Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL 12. ^{{cite web | url=http://legis.la.gov/Legis/Law.aspx?d=98877 | title=Louisiana State Legislature | accessdate=3 September 2015}} External links
6 : Designer drugs|Entactogens and empathogens|Entheogens|Phenol ethers|Psychedelic tryptamines|Allyl compounds |
||||||||||||||||||||||||||||||||||||||||||||||
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。