词条 | Hexapropymate |
释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 447909129 | IUPAC_name = 1-prop-2-yn-1-ylcyclohexyl carbamate | image = Hexapropymate2d.png | width = 160 | image2 = Hexapropymate3d.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 358-52-1 | ATC_prefix = N05 | ATC_suffix = CM10 | PubChem = 9661 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2104292 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 0J9RN2PRJ7 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 9280 | smiles = O=C(OC1(CCCCC1)CC#C)N | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C10H15NO2/c1-2-6-10(13-9(11)12)7-4-3-5-8-10/h1H,3-8H2,(H2,11,12) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = MIRHIEAGDGUXKL-UHFFFAOYSA-N | C=10 | H=15 | N=1 | O=2 | molecular_weight = 181.232 g/mol }}Hexapropymate is a hypnotic/sedative. It has effects similar to those of barbiturates and was used in the 1970s-1980s in the treatment of insomnia before being replaced with newer drugs with improved safety profiles.[1] References1. ^{{Cite journal | last1 = Gustafsson | first1 = L. L. | last2 = Berg | first2 = A. | last3 = Magnusson | first3 = A. | last4 = Malmlund | first4 = H. O. | last5 = Sandell | first5 = B. M. | last6 = Stig | first6 = R. | title = Hexapropymate self-poisoning causes severe and long-lasting clinical symptoms | journal = Medical Toxicology and Adverse Drug Experience | volume = 4 | issue = 4 | pages = 295–301 | year = 1989 | pmid = 2770531 | doi=10.1007/bf03259914}} {{Hypnotics and sedatives}}{{GABAAR PAMs}}{{sedative-stub}} 3 : Carbamates|GABAA receptor positive allosteric modulators|Alkynes |
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