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词条 Hexapropymate
释义

  1. References

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 447909129
| IUPAC_name = 1-prop-2-yn-1-ylcyclohexyl carbamate
| image = Hexapropymate2d.png
| width = 160
| image2 = Hexapropymate3d.png
| tradename =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 358-52-1
| ATC_prefix = N05
| ATC_suffix = CM10
| PubChem = 9661
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 2104292
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 0J9RN2PRJ7
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 9280
| smiles = O=C(OC1(CCCCC1)CC#C)N
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C10H15NO2/c1-2-6-10(13-9(11)12)7-4-3-5-8-10/h1H,3-8H2,(H2,11,12)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = MIRHIEAGDGUXKL-UHFFFAOYSA-N
| C=10 | H=15 | N=1 | O=2
| molecular_weight = 181.232 g/mol
}}Hexapropymate is a hypnotic/sedative. It has effects similar to those of barbiturates and was used in the 1970s-1980s in the treatment of insomnia before being replaced with newer drugs with improved safety profiles.[1]

References

1. ^{{Cite journal | last1 = Gustafsson | first1 = L. L. | last2 = Berg | first2 = A. | last3 = Magnusson | first3 = A. | last4 = Malmlund | first4 = H. O. | last5 = Sandell | first5 = B. M. | last6 = Stig | first6 = R. | title = Hexapropymate self-poisoning causes severe and long-lasting clinical symptoms | journal = Medical Toxicology and Adverse Drug Experience | volume = 4 | issue = 4 | pages = 295–301 | year = 1989 | pmid = 2770531 | doi=10.1007/bf03259914}}
{{Hypnotics and sedatives}}{{GABAAR PAMs}}{{sedative-stub}}

3 : Carbamates|GABAA receptor positive allosteric modulators|Alkynes

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