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词条 Corwin Hansch
释义

  1. Early life and childhood

  2. Education

  3. Career

  4. Death

  5. Notes

  6. Bibliography

  7. References

  8. See also

  9. External links

{{Infobox scientist
|birth_name = Corwin Herman Hansch
|birth_date = {{birth date|1918|10|6}}
|birth_place = Kenmare, North Dakota
|death_date = {{death date and age|2011|5|8|1918|10|6}}
|death_place = Claremont, California
|residence =
|citizenship =
|nationality = American
|ethnicity =
|field = Organic Chemistry
|work_institutions = Pomona College
Manhattan Project
|alma_mater = University of Illinois
New York University
|spouse = Gloria J. Hansch (nee Tomasulo) (m.1945?–2011) (his death) (1 child)
|doctoral_advisor =
|doctoral_students =
|known_for =
|author_abbrev_bot =
|author_abbrev_zoo =
|awards = Tolman Award (1975)
|influences =
|influenced =
|prizes =
|religion =
|footnotes =
|signature =
}}Corwin Herman Hansch (October 6, 1918 – May 8, 2011)[1] was a Professor of Chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.'[2]

Early life and childhood

He was born on October 6, 1918 in Kenmare, North Dakota.

Education

He earned a B.S. from the University of Illinois in 1940 and a Ph.D. from New York University in 1944.

Career

Hansch worked on the Manhattan Project at the University of Chicago and as a group leader at DuPont Nemours in Richland, Washington. In February 1946 he received an academic position at Pomona College.[3]

Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an undergraduate level.

Hansch may be best known as the father of the concept of quantitative structure-activity relationship (QSAR), the quantitative correlation of the physicochemical properties of molecules with their biological activities.

He is also noted for the Hansch equation, which is used in

  • Multivariate Statistics - Multivariate statistics is a set of statistical tools to analyse data (e.g., chemical and biological) matrices using regression and/or pattern recognition techniques.
  • Hansch Analysis - Hansch analysis is the investigation of the quantitative relationship between the biological activity of a series of compounds and their physicochemical substituent or global parameters representing hydrophobic, electronic, steric and other effects using multiple regression correlation methodology.
  • Hansch-Fujita constant - The Hansch-Fujita constant describes the contribution of a substituent to the lipophilicity of a compound.

Research Interests:

Organic Chemistry; Interaction of organic chemicals with living organisms, Quantitative Structure Activity Relationships (QSAR).

  • Fragment based regression analysis for quantitative structure-activity relationship (Hansch-analysis)

Death

He died of pneumonia on May 8, 2011 in Claremont, California at 92.[1]

Notes

His research group at Pomona College worked on QSAR studies and in building and expanding the database of chemical and physical data as C-QSAR and Bioloom. His postgraduate associates were Rajni Garg, Cynthia D Selassie, Suresh Babu Mekapati, and Alka Kurup.

The Journal of Computer-Aided Molecular Design carried four obituaries (as found in a Pubmed personal subject [ps] search).[4][5][6][7]

Bibliography

A preliminary search in WorldCat and in PubMed, two among many relevant bibliographic and citation indexes, shows the following:

  • Books: WorldCat shows "53 works in 204 publications in 4 languages and 2,004 library holdings" for Hansch as "author, editor, other".[8] The top item in the list is "Exploring QSAR" by Corwin Hansch, Albert Leo and David Hoekman, an ACS professional reference book in 28 editions published between 1995 and 2014.
  • Journal articles: 281 Pubmed records[9]
  • Reviews: authored 33 reviews as indexed in Pubmed[10]
  • Title word search: 56 Pubmed records[11]

The Pomona College Archives holds reprints of Hansch’s articles published between 1962 and 2009 in addition to other materials.[2]

References

1. ^1 {{cite news|last1=Maugh|first1=Thomas H. [II]|title=Corwin Hansch dies at 92; scientist whose advances led to new drugs and chemicals|url=http://www.latimes.com/local/obituaries/la-me-corwin-hansch-20110523-story.html|accessdate=5 August 2016|agency=Los Angeles Times|date=May 31, 2011}}
2. ^1 {{cite web|last1=Weber|first1=Jamie|title=Guide to the Corwin Hansch Collection|url=https://www.pomona.edu/sites/default/files/guide-to-the-hansch-collection.pdf|publisher=Pomona College Archives. Claremont, CA 91711|accessdate=5 August 2016|date=2013|page=3}}
3. ^{{cite web|title=1975 Tolman Award Medalist, Dr. Corwin Hansch, Carnegie Professor of Chemistry, Pomona College|url=http://scalacs.org/?page_id=1462|website=Southern California Section of the American Chemical Society}}
4. ^{{cite journal|last1=Martin|first1=Yvonne C|title=Remembrances of Corwin Hansch|journal=J Comput Aided Mol Des|date=Jun 29, 2011|volume=25|issue=6|pages=519–523|doi=10.1007/s10822-011-9452-y|pmid=21713458|bibcode=2011JCAMD..25..519M}}
5. ^{{cite journal|last1=Martin|first1=Yvonne C|last2=Stouch|first2=Terry|title=In tribute to Corwin Hansch, father of QSAR|journal=J Comput Aided Mol Des.|date=June 28, 2011|volume=25|issue=6|page=491|doi=10.1007/s10822-011-9449-6|pmid=21710390|bibcode=2011JCAMD..25..491M}}
6. ^{{cite journal|last1=Fujita|first1=Toshio|title=In memoriam professor Corwin Hansch: birth pangs of QSAR before 1961|journal=J Comput Aided Mol Des|date=June 22, 2011|volume=25|issue=6|pages=509–517|doi=10.1007/s10822-011-9450-0|pmid=21695492|bibcode=2011JCAMD..25..509F}}
7. ^{{cite journal|last1=Selassie|first1=Cynthia Rachel|title=Obituary: Corwin H. Hansch|journal=J Comput Aided Mol Des|date=June 21, 2011|volume=25|issue=6|pages=493–494|doi=10.1007/s10822-011-9445-x|pmid=21691812|bibcode=2011JCAMD..25..493S}}
8. ^{{cite web|title=[WorldCat search - books authored, edited, contributed]|url=http://www.worldcat.org/identities/lccn-n88-88289/|website=WorldCat|accessdate=August 5, 2016}}
9. ^{{cite web|title=281 articles, author search|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=(%22HANSCH+C%22%5Bau%5D+or+++%22HANSCH+CH%22+%5Bau%5D+or+++%22HANSCH+CW%22%5Bau%5D)+NOT+%22HANSCH+CF%22%5Bau%5D|website=Pubmed|accessdate=5 August 2016}}
10. ^{{cite web|title=33 authored reviews.|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=((%22HANSCH+C%22%5Bau%5D+or+%22HANSCH+CH%22+%5Bau%5D+or+%22HANSCH+CW%22%5Bau%5D)+NOT+%22HANSCH+CF%22%5Bau%5D+)+AND+review%5Bpt%5D|website=Pubmed|accessdate=5 August 2016}}
11. ^{{cite web|title=title word Pubmed records|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=Hansch%5Bti%5D+not+dye+laser|website=PubMed|accessdate=5 August 2016}}

See also

  • Hammett equation
  • Craig plot

External links

  • Example for Hansch equation and Hansch-Fujita constant
  • Corwin Hansch, The QSAR and Modelling Society News, October 1998
  • Corwin Hansch Collection, Pomona College Archives. Pomona College. Claremont, CA 91711, [https://www.pomona.edu/sites/default/files/guide-to-the-hansch-collection.pdf Guide to the Corwin Hansch Collection]
  • Former homepage - url, Pomona College
  • Corwin Hansch Award at the Hansch-Fujita Foundation, 2000-
{{Authority control}}{{DEFAULTSORT:Hansch, Corwin}}

9 : American pharmacologists|American academics|Manhattan Project people|2011 deaths|1918 births|People from Ward County, North Dakota|Guggenheim Fellows|Courant Institute of Mathematical Sciences alumni|University of Illinois alumni
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