KISU may refer to:

• KISU-FM, a radio station (91.1 FM) licensed to Pocatello, Idaho, United States
• KISU-TV, a television station (channel 10 analog/17 digital) licensed to Pocatello, Idaho, United States
• Kīsu, the Japanese name for Keese, a creature from the Legend of Zelda video game series
• Kisu-shelter an emergency shelter tent used in mountain rescue
• Kim Il-sung University in Pyongyang, North Korea

• Y-DNA haplogroups in populations of North Africa
• Y-DNA haplogroups in populations of the Caucasus
• Ydnekatchew Tessema
• YDNI
• YDOC
• YDOD
• Y. Dolmatovski
• YDOP
• YDPO
• Ydrapoej
• Ydredrotten
• Ydrefors
• Ydrissa Mbarke
• Ydrissa M'Barke
• Y-dropping
• YDS algorithm
• YDSE
• YD Square
• Ydun
• YDV
• Y Dwarf
• Ydw Valley and Fron Road Geological Exposures
• YDYS
• Y E
• Y.E.