| 词条 | David Bruce (microbiologist) |
| 释义 |
|name = Major-General Sir David Bruce |image =Davidbruce.JPG |caption = David Bruce |birth_date = 29 May 1855 |birth_place = Melbourne, Australia |death_date = {{death date and age|df=y|1931|11|27|1855|5|29}} |death_place = London |citizenship = British |nationality = Scottish |field = Microbiology |alma_mater = University of Edinburgh |known_for = trypanosome |prizes = Royal Medal {{small|(1904)}} Leeuwenhoek Medal {{small|(1915)}} Buchanan Medal {{small|(1922)}} Albert Medal {{small|(1923)}} Manson Medal {{small|(1923)}} |religion = |footnotes = |signature = }}Major-General Sir David Bruce {{post-nominals|country=GBR|KCB|FRS|FRCP|FRSE}}[1] (29 May 1855 in Melbourne – 27 November 1931 in London) was a Scottish pathologist and microbiologist who investigated Malta fever (later called brucellosis in his honour) and African trypanosomiasis (sleeping sickness in humans and nagana in animals). He discovered a protozoan parasite transmitted by insects, later named Trypanosoma brucei after him.[2] Working in the Army Medical Service and the Royal Army Medical Corps, his major scientific collaborator was his microbiologist wife Mary Elizabeth Bruce (née Steele), with whom he published more than thirty technical papers.[3] BiographyEarly life and educationBruce was born in Melbourne, Australia to Scottish parents: engineer David Bruce (from Airth) and his wife Jane Russell Hamilton (from Stirling), who had emigrated to Australia in the gold rush of 1850. He was an only child. He returned with his family to Scotland at the age of five. They lived at 1 Victoria Square in Stirling. He was educated at Stirling High School[4] and in 1869 began an apprenticeship in Manchester. However, a bout of pneumonia forced him to abandon this and re-assess his career.[5] He then decided to study zoology but later changed to medicine at the University of Edinburgh in 1876.[6] He graduated in 1881.[7] Medical careerAfter a brief period as a general practitioner in Reigate, Surrey (1881–83), where he met and married his wife Mary, he entered the Army Medical School in Hampshire at the Royal Victoria Hospital, Netley. He qualified the military examination in 1883 and joined the Army Medical Services (and served till 1919).[2] For his first post he joined the Royal Army Medical Corps in 1884 and was stationed in Valletta, Malta.[8] Bruce was appointed Assistant Professor of pathology at the Army Medical School in Netley in 1889, and served there for five years.[7] He returned to military field service in 1894 and was posted to Pietermaritzburg, Natal, South Africa. He was assigned to investigate the case of cattle and horse sickness (called nagana) in Zululand. On 27 October 1894, he and his wife moved to Ubombo Hill, where the disease was most prevalent. When the Second Boer War broke out in 1899, accompanied by his wife, he ran the field hospital during the Siege of Ladysmith (2 November 1899 until 28 February 1900). For his service during the war he was promoted to Lieutenant-Colonel. In 1900, he joined the army commission investigating dysentery in military camps, at the same time working for the Royal Society's sleeping sickness expedition.[2] Bruce served as a member of the Army Medical Service Advisory Board from 1902 to 1911. In 1914 he became Commander of the Royal Army Medical College, the position he held until his retirement as a Major-General in 1919. He was immediately appointed chairman of the governing body of the Lister Institute. During his career he published more than ninety-seven technical articles, of which about thirty of them were coauthored by his wife.[7] DeathHe died four days after his wife in 1931, during her memorial service. Both were cremated in London and their ashes are buried together in Valley Cemetery in Stirling, close to Stirling Castle, beneath a simple stone cross on the east side of the main north-south path, near the southern roundel. They had no children.[9] Scientific contributionsAt the time of his service in Malta, British soldiers suffered an outbreak of what was called the Malta fever. In 1886, he led the Malta Fever Commission that identified the organism that caused the fever as a bacterium Micrococcus melitensis (later renamed Brucella melitensis).[10] Themistocles Zammit, one of the members of the commission, discovered the cause of the fever in 1905. Bruce discouraged the experiments being carried by Zammit, and doubted his ability as a microbiologist. Eventually, when he learned of the positive results linking the fever with unpasteurized goat milk, Bruce tried to discredit the role of Zammit and take credit to himself. To a certain extent he succeeded, as it was renamed after him as brucellosis, however information about the role of Zammit has eventually surfaced.[11] When he was transferred to South Africa, Bruce was sent to Zululand in 1894 to investigate the outbreak of cattle disease which the native called nagana. In 1903, he identified the causative protozoan, and tsetse fly vector, of African trypanosomiasis ("sleeping sickness").[12] He was Surgeon-General for the duration of the First World War from 1914–19 at the Royal Army Medical College, Millbank, London.[13] Brucella is the genus and Brucellaceae is the family of the bacteria which was named after him, in recognition of his discoveries. Brucella melitensis is the cause of undulant fever in man and of abortion in goats. It is usually transmitted by goat's milk. Trypanosoma brucei,[14] the cause of sleeping sickness, is also named after him. Honours and awardsBruce was elected a Fellow of the Royal Society (FRS) in 1899. He served as editor of the Journal of the Royal Army Medical Corps between 1904 and 1908. He was the recipient of the Cameron prize of Edinburgh University in 1901. He received the Royal Society’s Royal Medal in 1904, the Mary Kingsley Medal in 1905, and the Stewart prize of the British Medical Association. He was Croonian Lecturer at the Royal College of Physicians in 1915.[7] He was awarded the Leeuwenhoek Medal in 1915, created a Companion of the Bath (CB) in the 1905 Birthday Honours, knighted in 1908 and upgraded to a Knight Commander of the Bath (KCB) in 1918.[1] He was president of the British Science Association during 1924–1925.[15] Bruce's name features on the frieze of the London School of Hygiene & Tropical Medicine. Twenty-three names of public health and tropical medicine pioneers were chosen to feature on the School building in Keppel Street when it was constructed in 1926.[16] References1. ^1 {{Cite journal | last1 = b. | first1 = J. R. | doi = 10.1098/rsbm.1932.0017 | title = Sir David Bruce. 1855-1931 | journal = Obituary Notices of Fellows of the Royal Society | volume = 1 |page=79 | year = 1932 | pmid = | pmc = }} 2. ^1 2 {{cite book|last1=Cook|first1=G.C.|title=Tropical Medicine: An Illustrated History of The Pioneers|date=2007|publisher=Elsevier Ltd.|location=Burlington (US)|isbn=978-0-08-055939-1|pages=145–156|url=https://books.google.com/books?id=iB_ibIXxhOMC&dq=tropical+medicine+illustrated&source=gbs_navlinks_s}} 3. ^{{cite web|title=Sir David Bruce|url=http://www.whonamedit.com/doctor.cfm/871.html|website=www.whonamedit.com|publisher=Ole Daniel Enersen|accessdate=30 January 2017|language=en}} 4. ^{{cite magazine|title=Bruce, Colonel David|magazine=Who's Who|year=1907|volume= 59|pages=234–235|url=https://books.google.com/books?id=yEcuAAAAYAAJ&pg=PA234}} 5. ^Stirling's Talking Stones {{ISBN|1-870-542-48-7}} 6. ^{{cite web|url=http://www.rse.org.uk/fellowship/fells_indexp1.pdf|title=Former RSE Fellows 1783–2002|publisher=Royal Society of Edinburgh|accessdate=19 September 2010|deadurl=yes|archiveurl=https://web.archive.org/web/20061004113545/http://www.rse.org.uk/fellowship/fells_indexp1.pdf|archivedate=4 October 2006|df=dmy-all}} 7. ^1 2 3 {{cite web|last1=Brown|first1=G. H.|title=David (Sir) Bruce|url=http://munksroll.rcplondon.ac.uk/Biography/Details/623|website=munksroll.rcplondon.ac.uk|publisher=Royal College of Physicians of London|accessdate=30 January 2017}} 8. ^{{cite journal |author=SACHS A |title=A memorial to major-general Sir David Bruce, K.C.B., F.R.S |journal=Journal of the Royal Army Medical Corps |volume=97 |issue=4 |pages=293–5 |date=October 1951 |pmid=14889518}} 9. ^http://www.royalsoced.org.uk/cms/files/fellows/biographical_index/fells_indexp1.pdf 10. ^{{cite book |last1=Corbel |first1=M.J. |last2=Banai |first2=M. |chapter=Brucella |title=Bergey's Manual of Systematics of Archaea and Bacteria |date=2015 |pages=1–30 |doi=10.1002/9781118960608.gbm00807 |publisher=John Wiley & Sons}} 11. ^{{cite journal |journal=Journal of the Royal Society of Medicine |last=Wyatt |first=Harold Vivian |date=October 2005 |title=How Themistocles Zammit found Malta Fever (brucellosis) to be transmitted by the milk of goats |volume=98 |issue=10 |pages=451–454 |pmc=1240100 |pmid=16199812 |doi=10.1258/jrsm.98.10.451 |oclc=680110952 }} 12. ^{{cite journal |author=Ellis, H. |title=Sir David Bruce, a pioneer of tropical medicine |journal=British Journal of Hospital Medicine |volume=67 |issue=3 |page=158 |date=March 2006 |pmid=16562450}} 13. ^S R Christophers: 'Bruce, Sir David (1855–1931)' (rev. Helen J Power), Oxford Dictionary of National Biography, Oxford University Press, 2004; online edn, Oct 2008, accessed 23 May 2014 14. ^{{cite journal |author1=Joubert, J.J.; Schutte, C.H.; Irons, D.J.; Fripp, P.J. |title=Ubombo and the site of David Bruce's discovery of Trypanosoma brucei |journal=Transactions of the Royal Society of Tropical Medicine and Hygiene |volume=87 |issue=4 |pages=494–5 |year=1993 |pmid=8249096 |doi=10.1016/0035-9203(93)90056-V}} 15. ^[https://archive.org/stream/reportofbritisha25adva#page/n35/mode/2up Presidential Address to the British Association Meeting, held at Toronto in 1924] 16. ^{{Cite web|url=http://www.lshtm.ac.uk/library/archives/history/frieze/index.html|title=Behind the Frieze|last=|first=|date=|website=LSHTM|archive-url=https://web.archive.org/web/20120703044002/http://www.lshtm.ac.uk/library/archives/history/frieze/index.html|archive-date=2012-07-03|dead-url=yes|access-date=21 February 2017}} Bibliography
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15 : Scottish inventors|Scottish microbiologists|Scottish pathologists|People educated at Stirling High School|Alumni of the University of Edinburgh|1855 births|1931 deaths|Royal Medal winners|Fellows of the Royal College of Physicians|Fellows of the Royal Society of Edinburgh|Fellows of the Royal Society|Knights Commander of the Order of the Bath|Leeuwenhoek Medal winners|Manson medal winners|Royal Army Medical Corps officers |
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