| 词条 | Dry media reaction |
| 释义 |
A dry media reaction or solid-state reaction or solventless reaction is a chemical reaction system in the absence of a solvent. The drive for the development of dry media reactions in chemistry is
Drawbacks to overcome:
In one type of solventless reaction a liquid reactant is used neat, for instance the reaction of 1-bromonaphthalene with Lawesson's reagent is done with no added liquid solvent, but the 1-bromonaphthalene acts as a solvent. A reaction which is closer to a true solventless reaction is a Knoevenagel condensation of ketones with (malononitrile) where a 1:1 mixture of the two reactants (and ammonium acetate) is irradiated in a microwave oven. Colin Raston's research group have been responsible for a number of new solvent free reactions. In some of these reactions all the starting materials are solids, they are ground together with some sodium hydroxide to form a liquid, which turns into a paste which then hardens to a solid. In another development the two components of an aldol reaction are combined together with the asymmetric catalyst S-proline in a ball mill in a mechanosynthesis. The reaction product has 97% enantiomeric excess. A reaction rate acceleration is observed in several systems when a homogeneous solvent system is rapidly evaporated in a rotavap in a vacuum, one of them a Wittig reaction. The reaction goes to completion in 5 minutes with immediate evaporation whereas the same reaction in solution after the same 5 minutes (dichloromethane) has only 70% conversion and even after 24 hours some of the aldehyde remains. Bibliography
1 : Chemical reactions |
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