RI-1 may refer to:

• Rhode Island's 1st congressional district
• RI-1 (chemical), an experimental oncology drug
• U.S. Route 1 in Rhode Island, a portion of a north–south highway in the United States

• John Warcup Cornforth
• John Ward
• John Ward, 1st Earl of Dudley
• John Wardle (businessman)
• John wardley
• John Ward Studebaker
• John Ware (cowboy)
• John Wark
• John Warne
• John Warner
• John Warnock
• John Warren
• John Warren, 3rd Baron de Tabley
• John Warren, Lord De Tabley
• John Warwick Montgomery
• John Waterbury
• John Waters
• John Waters (actor)
• John Waters (columnist)
• John Waters (director born 1893)
• John Waters (disambiguation)
• John Watkins (Australian politician)
• John Watson
• John Watson (Australian politician)
• John Watson (driver)