| 词条 | Small nucleolar RNA MBII-202 |
| 释义 |
| Name = Small nucleolar RNA MBII-202 | image = RF00324.jpg | width = | caption = Predicted secondary structure and sequence conservation of snoMBII-202 | Symbol = snoMBII-202 | AltSymbols = | Rfam = RF00324 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; C/D-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} Small nucleolar RNA MBII-202 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA MBII-202 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2] snoRNA MBII-202 was originally cloned from mouse brain tissues.[3] References1. ^{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–8 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }} 2. ^{{cite journal | vauthors = Kiss T | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | issue = 2 | pages = 145–8 | date = April 2002 | pmid = 12007400 | pmc = | doi = 10.1016/S0092-8674(02)00718-3 }} 3. ^{{cite journal | vauthors = Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = The EMBO Journal | volume = 20 | issue = 11 | pages = 2943–53 | date = June 2001 | pmid = 11387227 | pmc = 125495 | doi = 10.1093/emboj/20.11.2943 }} External links
1 : Small nuclear RNA |
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