| 词条 | Foot-and-mouth disease virus |
| 释义 |
| image = Electronmicrograph of the foot-and-mouth disease virus.png | image_alt = Electronmicrograph of "Foot-and-mouth disease virus" | image_caption = Electronmicrograph of Foot-and-mouth disease virus | parent = Aphthovirus | species = Foot-and-mouth disease virus | synonyms = | synonyms_ref = | subdivision_ranks = | subdivision = }} Foot-and-mouth disease virus (FMDV) is the pathogen that causes foot-and-mouth disease.[1] It is a picornavirus, the prototypical member of the genus Aphthovirus. The disease, which causes vesicles (blisters) in the mouth and feet of bovids, suids, ovids, caprids and other cloven-hoofed animals is highly infectious and a major plague of animal farming. The virus particle (25-30 nm) has an icosahedral capsid made of protein, without envelope, containing a single strand of ribonucleic acid (RNA) containing a positive encoding of its genome. When the virus comes in contact with the membrane of a host cell, it binds to a receptor site and triggers a folding-in of the membrane. Once the virus is inside the host cell, the capsid dissolves, and the RNA gets replicated, and translated into viral proteins by the cell's ribosomes using a cap-independent mechanism driven by the internal ribosome entry site element. The synthesis of viral proteins include 2A 'cleavage' during translation. They include proteases that inhibit the synthesis of normal cell proteins, and other proteins that interact with different components of the host cell. The infected cell ends up producing large quantities of viral RNA and capsid proteins, which are assembled to form new viruses. After assembly, the host cell lyses (bursts) and releases the new viruses.[2] Foot-and-mouth disease virus occurs in seven major serotypes: O, A, C, SAT-1, SAT-2, SAT-3, and Asia-1. These serotypes show some regionality, and the O serotype is most common. References1. ^{{cite journal |vauthors=Carrillo C, Tulman ER, Delhon G |title=Comparative Genomics of Foot-and-Mouth Disease Virus |journal=J. Virol. |volume=79 |issue=10 |pages=6487–504 |date=May 2005 |pmid=15858032 |pmc=1091679 |doi=10.1128/JVI.79.10.6487-6504.2005 |display-authors=etal}} {{Viral cutaneous conditions}}{{Taxonbar|from=Q1911079}}{{DEFAULTSORT:Foot-And-Mouth Disease Virus}}{{Virus-stub}}2. ^{{cite book |chapterurl=http://www.horizonpress.com/hsp/abs/absavir.html|vauthors=Martinez-Salas E, Saiz M, Sobrino F|year=2008|chapter=Foot-and-Mouth Disease Virus|title=Animal Viruses: Molecular Biology|publisher=Caister Academic Press|pages=1–38|isbn=978-1-904455-22-6}} 2 : Aphthoviruses|Animal viral diseases |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。