| 词条 | Agelasimine |
| 释义 |
Agelasimines are a group of adenine-related bicyclic diterpenoids isolated from the orange sponge Agelas mauritania.[1] Their chemical structures are closely related to the agelasines. Both groups of compounds display a range of biological activities, such as cytotoxicity, inhibition of adenosine transfer into rabbit erythrocytes (red blood cells), Ca2+ channel antagonistic action, α1 adrenergic blockade and others.[2][3] Both compounds have been reproduced in the laboratory by organic synthesis. References1. ^{{cite journal|last1=Ohba|first1=Masashi|last2=Iizuka|first2=Kazuaki|last3=Ishibashi|first3=Hiroyuki|last4=Fujii|first4=Tozo|title=Syntheses and absolute configurations of the marine sponge purines (+)-agelasimine-A and (+)-agelasimine-B|journal=Tetrahedron|date=December 1997|volume=53|issue=50|pages=16977–16986|doi=10.1016/S0040-4020(97)10120-X}} {{organic-compound-stub}}2. ^{{cite journal|last1=Fathi-Afshar|first1=R.|last2=Allen|first2=T. M.|title=Biologically active metabolites from|journal=Canadian Journal of Chemistry|date=January 1988|volume=66|issue=1|pages=45–50|doi=10.1139/v88-006}} 3. ^{{cite journal|last1=Fathi-Afshar|first1=R.|last2=Allen|first2=T. M.|last3=Krueger|first3=C. A.|last4=Cook|first4=D. A.|last5=Clanachan|first5=A. S.|last6=Vriend|first6=R.|last7=Baer|first7=H. P.|last8=Cass|first8=C. E.|title=Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge|journal=Canadian Journal of Physiology and Pharmacology|date=April 1989|volume=67|issue=4|pages=276–281|doi=10.1139/y89-045}} 2 : Diterpene alkaloids|Purines |
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