“4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate”的意思、由来-开放百科全书

词条

4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate

释义

References

{{chembox
| verifiedrevid = 428795578
| ImageFile=4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate.png
| ImageSize=250px
| IUPACName= [(2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2R,3S)-2,4-dihydroxy-3-methyl-3-phosphonooxybutoxy]-hydroxyphosphoryl] hydrogen phosphate
| OtherNames=
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=263016-95-1
| PubChem=443200
| SMILES=C[C@](CO)([C@@H](COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=NC2=O)N)O)O)O)OP(=O)(O)O
| MeSHName=4-diphosphocytidyl-2C+methylerythritol+2-phosphate
|Section2={{Chembox Properties
| Formula=C₁₄H₂₆N₃O₁₇P₃
| MolarMass=601.29 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}

4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (or CDP-MEP, 4-diphosphocytidyl-2C methylerythritol 2-phosphate) is an intermediate in the MEP pathway of isoprenoid precursor biosynthesis.

It is formed by CDP-ME kinase (IspE) and is a substrate for 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF).^[1]

References

1. ^{{Cite journal|title = Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF, a potential drug target|vauthors = Narayanasamy P, Eoh H, Brennan PJ, Crick DC|date = 2010|journal = Chem Biol (Cell Press)|doi = 10.1016/j.chembiol.2010.01.013|pmid = 20189102|access-date =|pmc=2837070|volume=17|pages=117–22}}

{{DEFAULTSORT:Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate, 4-}}{{organic-compound-stub}}

1 : Organophosphates

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