| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[1][2][3]Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[3]References1. ^{{cite journal | vauthors = Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T | title = Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins | journal = Oncogene | volume = 9 | issue = 4 | pages = 1057–63 |date=Apr 1994 | pmid = 8134109 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Takai S, Chan AM, Yamada K, Miki T | title = Assignment of the human TIM proto-oncogene to 7q33→q35 | journal = Cancer Genet Cytogenet | volume = 83 | issue = 1 | pages = 87–9 |date=Oct 1995 | pmid = 7656213 | pmc = | doi =10.1016/S0165-4608(95)00017-8 }}
3. ^1 {{cite web | title = Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7984| accessdate = }}
External links- {{UCSC gene info|ARHGEF5}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Snyder JT, Worthylake DK, Rossman KL |title=Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. |journal=Nat. Struct. Biol. |volume=9 |issue= 6 |pages= 468–75 |year= 2002 |pmid= 12006984 |doi= 10.1038/nsb796 |display-authors=etal}}
- {{cite journal | vauthors=Wistow G, Bernstein SL, Wyatt MK |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 171–84 |year= 2002 |pmid= 12107413 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Umetsu DT, Dekruyff RH |title=Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment. |journal=Ann. N. Y. Acad. Sci. |volume=1029 |issue= 1|pages= 88–93 |year= 2005 |pmid= 15681748 |doi= 10.1196/annals.1309.012 }}
- {{cite journal | vauthors=Benzinger A, Muster N, Koch HB |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |display-authors=etal}}
- {{cite journal | vauthors=Zhang Y, Wolf-Yadlin A, Ross PL |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |display-authors=etal}}
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