Guido Mazzoni may refer to:

• Guido Mazzoni (sculptor) (c. 1445–1518), sculptor
• Guido Mazzoni (poet) (1859–1943), poet and professor

• Virginia State Route 676 (Loudoun County)
• Virginia State Route 676 (Louisa County)
• Virginia State Route 676 (Lunenburg County)
• Virginia State Route 676 (Madison County)
• Virginia State Route 676 (Mathews County)
• Virginia State Route 676 (Mecklenburg County)
• Virginia State Route 676 (Middlesex County)
• Virginia State Route 676 (Montgomery County)
• Virginia State Route 676 (Nelson County)
• Virginia State Route 676 (New Kent County)
• Virginia State Route 676 (Northampton County)
• Virginia State Route 676 (Northumberland County)
• Virginia State Route 676 (Nottoway County)
• Virginia State Route 676 (Orange County)
• Virginia State Route 676 (Page County)
• Virginia State Route 676 (Patrick County)
• Virginia State Route 676 (Pittsylvania County)
• Virginia State Route 676 (Powhatan County)
• Virginia State Route 676 (Prince Edward County)
• Virginia State Route 676 (Prince George County)
• Virginia State Route 676 (Prince William County)
• Virginia State Route 676 (Pulaski County)
• Virginia State Route 676 (Rappahannock County)
• Virginia State Route 676 (Richmond County)
• Virginia State Route 676 (Roanoke County)