IOM may refer to:

• Indian Order of Merit, a military and civilian decoration in British India.
• Infraorbital margin, the lower margin of the eye socket
• Institute of Medicine, a not-for-profit, non-governmental American organization founded in 1970
• Institute of Medicine, Nepal, a medical school in Kathmandu, Nepal
• Institute of Occupational Medicine in the UK
• Institute of Oriental Manuscripts of the Russian Academy of Sciences
• Integrated Object Model, an Application Programming Interface used in SAS (software) 9.1+ Integration Technologies
• International Organization for Migration, an intergovernmental organization
• International One Metre (radiosailing), a class of radio sailing boat
• Intraoperative monitoring (neurophysiogical testing during surgery)
• IOM soybeans, an industrial designation for soybeans from the U.S. states of Indiana, Ohio, and Michigan
• ISDN-oriented Modular Interface
• Isle of Man, a self-governing British Crown Dependency, located in the Irish Sea
• Isle of Man Airport, its IATA airport code

• Jupiter (mythology), or Jupiter Optimus Maximus, king of the Roman gods

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