“ICA1”的意思、由来-开放百科全书

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[3]

References

1. ^{{cite journal |vauthors=Miyazaki I, Gaedigk R, Hui MF, Cheung RK, Morkowski J, Rajotte RV, Dosch HM | title = Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes | journal = Biochim Biophys Acta | volume = 1227 | issue = 1–2 | pages = 101–4 |date=Nov 1994 | pmid = 7918678 | pmc = | doi = 10.1016/0925-4439(94)90113-9}}
2. ^{{cite journal |vauthors=Mally MI, Cirulli V, Hayek A, Otonkoski T | title = ICA69 is expressed equally in the human endocrine and exocrine pancreas | journal = Diabetologia | volume = 39 | issue = 4 | pages = 474–80 |date=Sep 1996 | pmid = 8777998 | pmc = | doi =10.1007/BF00400680 }}
3. ^¹{{cite web | title = Entrez Gene: ICA1 islet cell autoantigen 1, 69kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3382| accessdate = }}

Further reading

{{cite journal | author=Nepom GT |title=Glutamic acid decarboxylase and other autoantigens in IDDM |journal=Curr. Opin. Immunol. |volume=7 |issue= 6 |pages= 825–30 |year= 1996 |pmid= 8679127 |doi=10.1016/0952-7915(95)80055-7 }}

{{cite journal |vauthors=Thai AC, Ng WY, Lui KF, Cheah JS |title=Islet cell and thyroid autoimmunity in Chinese patients with IDDM |journal=Diabetes Care |volume=18 |issue= 4 |pages= 586–7 |year= 1996 |pmid= 7497880 |doi= 10.2337/diacare.18.4.586 }}

{{cite journal | author=Martin S |title=Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis |journal=Diabetologia |volume=38 |issue= 3 |pages= 351–5 |year= 1995 |pmid= 7758883 |doi=10.1007/BF00400641 |name-list-format=vanc| author2=Kardorf J | author3=Schulte B | display-authors=3 | last4=Lampeter | first4=E. F. | last5=Gries | first5=F. A. | last6=Melchers | first6=I. | last7=Wagner | first7=R. | last8=Bertrams | first8=J. | last9=Roep | first9=B. O. }}

{{cite journal | author=Miyazaki I |title=T cell activation and anergy to islet cell antigen in type I diabetes |journal=J. Immunol. |volume=154 |issue= 3 |pages= 1461–9 |year= 1995 |pmid= 7822811 |doi= |name-list-format=vanc| author2=Cheung RK | author3=Gaedigk R | display-authors=3 | last4=Hui | first4=MF | last5=Van Der Meulen | first5=J | last6=Rajotte | first6=RV | last7=Dosch | first7=HM }}

{{cite journal | author=Lampasona V |title=Sera from patients with IDDM and healthy individuals have antibodies to ICA69 on western blots but do not immunoprecipitate liquid phase antigen |journal=J. Autoimmun. |volume=7 |issue= 5 |pages= 665–74 |year= 1995 |pmid= 7840858 |doi= 10.1006/jaut.1994.1051 |name-list-format=vanc| author2=Ferrari M | author3=Bosi E | display-authors=3 | last4=Pastore | first4=Matteo Rocco | last5=Bingley | first5=Penelope J. | last6=Bonifacio | first6=Ezio }}

{{cite journal | author=Gaedigk R |title=ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22 |journal=Cytogenet. Cell Genet. |volume=66 |issue= 4 |pages= 274–6 |year= 1994 |pmid= 8162706 |doi=10.1159/000133711 |name-list-format=vanc| author2=Duncan AM | author3=Miyazaki I | display-authors=3 | last4=Robinson | first4=B.H. | last5=Dosch | first5=H.-M. }}

{{cite journal | author=Pietropaolo M |title=Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen |journal=J. Clin. Invest. |volume=92 |issue= 1 |pages= 359–71 |year= 1993 |pmid= 8326004 |doi=10.1172/JCI116574 | pmc=293615 |name-list-format=vanc| author2=Castaño L | author3=Babu S | display-authors=3 | last4=Buelow | first4=R | last5=Kuo | first5=Y L | last6=Martin | first6=S | last7=Martin | first7=A | last8=Powers | first8=A C | last9=Prochazka | first9=M }}

{{cite journal |vauthors=Karges W, Pietropaolo M, Ackerley CA, Dosch HM |title=Gene expression of islet cell antigen p69 in human, mouse, and rat |journal=Diabetes |volume=45 |issue= 4 |pages= 513–21 |year= 1996 |pmid= 8603775 |doi=10.2337/diabetes.45.4.513 }}

{{cite journal |vauthors=Martin S, Lampasona V, Dosch M, Pietropaolo M |title=Islet cell autoantigen 69 antibodies in IDDM |journal=Diabetologia |volume=39 |issue= 6 |pages= 747 |year= 1996 |pmid= 8781774 |doi=10.1007/BF00418550 }}

{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}

{{cite journal | author=Gaedigk R |title=Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity |journal=Genomics |volume=38 |issue= 3 |pages= 382–91 |year= 1997 |pmid= 8975715 |doi= 10.1006/geno.1996.0641 |name-list-format=vanc| author2=Karges W | author3=Hui MF | display-authors=3 | last4=Scherer | first4=Stephen W. | last5=Dosch | first5=Hans-Michael }}

{{cite journal |vauthors=Stassi G, Schloot N, Pietropaolo M |title=Islet cell autoantigen 69 kDa (ICA69) is preferentially expressed in the human islets of Langerhans than exocrine pancreas |journal=Diabetologia |volume=40 |issue= 1 |pages= 120–2 |year= 1997 |pmid= 9028728 |doi= }}

{{cite journal | author=Rønningen KS |title=Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69 |journal=J. Autoimmun. |volume=11 |issue= 3 |pages= 223–31 |year= 1998 |pmid= 9693970 |doi= 10.1006/jaut.1998.0199 |name-list-format=vanc| author2=Atrazhev A | author3=Luo L | display-authors=3 | last4=Luo | first4=Colin | last5=Smith | first5=Dean K | last6=Korbutt | first6=Gregory | last7=Rajotte | first7=Ray V | last8=Elliott | first8=John F }}

{{cite journal | author=Kerokoski P |title=Production of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritis |journal=Autoimmunity |volume=29 |issue= 4 |pages= 281–9 |year= 1999 |pmid= 10433084 |doi=10.3109/08916939908994748 |name-list-format=vanc| author2=Ilonen J | author3=Gaedigk R | display-authors=3 | last4=Dosch | first4=Hans-Michael | last5=Knip | first5=Mikael | last6=Hakala | first6=Markku | last7=Hinkkanene | first7=Ari }}

{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}

{{cite journal | author=Winer S |title=Primary Sjögren's syndrome and deficiency of ICA69 |journal=Lancet |volume=360 |issue= 9339 |pages= 1063–9 |year= 2002 |pmid= 12383988 |doi=10.1016/S0140-6736(02)11144-5 |name-list-format=vanc| author2=Astsaturov I | author3=Cheung R | display-authors=3 | last4=Tsui | first4=Hubert | last5=Song | first5=Aihua | last6=Gaedigk | first6=Roger | last7=Winer | first7=Daniel | last8=Sampson | first8=Anastasia | last9=McKerlie | first9=Colin }}

{{cite journal | author=Friday RP |title=Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 853–63 |year= 2003 |pmid= 12409289 |doi= 10.1074/jbc.M210175200 |name-list-format=vanc| author2=Pietropaolo SL | author3=Profozich J | display-authors=3 | last4=Trucco | first4=M | last5=Pietropaolo | first5=M }}