“Integrin beta 7”的意思、由来-开放百科全书

Structure

Like all integrin subunits, β{{sub|7}} is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.^[4] Beginning with the apical end of the protein, farthest from the cell membrane, the β{{sub|7}} is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.^[5]

References

1. ^{{cite journal | vauthors = Erle DJ, Rüegg C, Sheppard D, Pytela R | title = Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 11009–16 | date = Jun 1991 | pmid = 2040616 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: ITGB7 integrin, beta 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3695| accessdate = }}
3. ^{{cite journal | vauthors = Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ | title = Anti-integrin monoclonal antibodies | journal = Journal of Cell Science | volume = 122 | issue = Pt 22 | pages = 4009–11 | date = Nov 2009 | pmid = 19910492 | pmc = 3329622 | doi = 10.1242/jcs.056770 }}
4. ^{{cite journal | vauthors = Carman CV, Springer TA | title = Integrin avidity regulation: are changes in affinity and conformation underemphasized? | journal = Current Opinion in Cell Biology | volume = 15 | issue = 5 | pages = 547–56 | date = Oct 2003 | pmid = 14519389 | doi = 10.1016/j.ceb.2003.08.003 }}
5. ^{{cite journal | vauthors = Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA | title = Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion | journal = The Journal of Cell Biology | volume = 196 | issue = 1 | pages = 131–46 | date = Jan 2012 | pmid = 22232704 | pmc = 3255974 | doi = 10.1083/jcb.201110023 }}
6. ^{{cite journal | vauthors = Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B | title = The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27459–66 | date = Oct 1998 | pmid = 9765275 | doi = 10.1074/jbc.273.42.27459 }}

Further reading

{{cite journal | vauthors = Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ | title = Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering | journal = The Journal of Cell Biology | volume = 117 | issue = 1 | pages = 179–89 | date = Apr 1992 | pmid = 1372909 | pmc = 2289398 | doi = 10.1083/jcb.117.1.179 }}

{{cite journal | vauthors = Chan BM, Elices MJ, Murphy E, Hemler ME | title = Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY | journal = The Journal of Biological Chemistry | volume = 267 | issue = 12 | pages = 8366–70 | date = Apr 1992 | pmid = 1373725 | doi = }}

{{cite journal | vauthors = Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW | title = The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1 | journal = International Immunology | volume = 4 | issue = 9 | pages = 1031–40 | date = Sep 1992 | pmid = 1382574 | doi = 10.1093/intimm/4.9.1031 }}

{{cite journal | vauthors = Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW | title = Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization | journal = Mammalian Genome | volume = 2 | issue = 4 | pages = 272–3 | year = 1992 | pmid = 1543919 | doi = 10.1007/BF00355438 }}

{{cite journal | vauthors = Yuan QA, Jiang WM, Krissansen GW, Watson JD | title = Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains | journal = International Immunology | volume = 3 | issue = 12 | pages = 1373–4 | date = Dec 1991 | pmid = 1777426 | doi = 10.1093/intimm/3.12.1373 }}

{{cite journal | vauthors = Yuan QA, Jiang WM, Krissansen GW, Watson JD | title = Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains | journal = International Immunology | volume = 2 | issue = 11 | pages = 1097–108 | year = 1991 | pmid = 2083230 | doi = 10.1093/intimm/2.11.1097 }}

{{cite journal | vauthors = Erle DJ, Brown T, Christian D, Aris R | title = Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 10 | issue = 3 | pages = 237–44 | date = Mar 1994 | pmid = 7509610 | doi = 10.1165/ajrcmb.10.3.7509610 }}

{{cite journal | vauthors = Postigo AA, Sánchez-Mateos P, Lazarovits AI, Sánchez-Madrid F, de Landázuri MO | title = Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes | journal = Journal of Immunology | volume = 151 | issue = 5 | pages = 2471–83 | date = Sep 1993 | pmid = 7689608 | doi = }}

{{cite journal | vauthors = Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM | title = Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution | journal = The Journal of Biological Chemistry | volume = 269 | issue = 8 | pages = 6016–25 | date = Feb 1994 | pmid = 8119947 | doi = }}

{{cite journal | vauthors = Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ | title = Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1 | journal = Journal of Immunology | volume = 159 | issue = 3 | pages = 1497–505 | date = Aug 1997 | pmid = 9233649 | doi = }}

{{cite journal | vauthors = Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH | title = The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition | journal = Structure | volume = 6 | issue = 6 | pages = 793–801 | date = Jun 1998 | pmid = 9655832 | doi = 10.1016/S0969-2126(98)00080-X }}

{{cite journal | vauthors = Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B | title = The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27459–66 | date = Oct 1998 | pmid = 9765275 | doi = 10.1074/jbc.273.42.27459 }}

{{cite journal | vauthors = Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB | title = Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin | journal = The Journal of Experimental Medicine | volume = 191 | issue = 9 | pages = 1555–67 | date = May 2000 | pmid = 10790430 | pmc = 2213439 | doi = 10.1084/jem.191.9.1555 }}

{{cite journal | vauthors = Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB | title = The role of alpha and beta chains in ligand recognition by beta 7 integrins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25652–64 | date = Aug 2000 | pmid = 10837471 | doi = 10.1074/jbc.M001228200 }}

{{cite journal | vauthors = Puig-Kröger A, Sanz-Rodríguez F, Longo N, Sánchez-Mateos P, Botella L, Teixidó J, Bernabéu C, Corbí AL | title = Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells | journal = Journal of Immunology | volume = 165 | issue = 8 | pages = 4338–45 | date = Oct 2000 | pmid = 11035069 | doi = 10.4049/jimmunol.165.8.4338 }}

{{cite journal | vauthors = Guilliano MJ, Foxx-Orenstein AE, Lebman DA | title = The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction | journal = Journal of Immunology | volume = 166 | issue = 4 | pages = 2179–85 | date = Feb 2001 | pmid = 11160270 | doi = 10.4049/jimmunol.166.4.2179 }}

{{cite journal | vauthors = Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH | title = Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration | journal = Nature Cell Biology | volume = 3 | issue = 12 | pages = 1060–8 | date = Dec 2001 | pmid = 11781567 | doi = 10.1038/ncb1201-1060 }}

{{cite journal | vauthors = Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH | title = Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 5 | pages = 2272–7 | date = Mar 2003 | pmid = 12606711 | pmc = 151330 | doi = 10.1073/pnas.262791999 }}

Structure

Interactions

References

Further reading

External links