| 释义 |
- Roles in disease
- References
{{infobox gene}}Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member 5 (IL1F5).[1][2][3][4]The protein is known to inhibit the effects of Interleukin-36 cytokines (IL-36α, IL-36β and IL-36γ) via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects.[5] Roles in diseaseMutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised pustular psoriasis, acrodermatitis continua suppurativa Hallopeau (ACH) and acute generalized exanthematous pustulosis (AGEP).[6] References1. ^{{cite journal |vauthors=Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE | title = Four new members expand the interleukin-1 superfamily | journal = J Biol Chem | volume = 275 | issue = 2 | pages = 1169–75 |date=Feb 2000 | pmid = 10625660 | pmc = | doi =10.1074/jbc.275.2.1169 }}
2. ^{{cite journal |vauthors=Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE | title = IL1HY1: A novel interleukin-1 receptor antagonist gene | journal = Biochem Biophys Res Commun | volume = 263 | issue = 3 | pages = 702–6 |date=Nov 1999 | pmid = 10512743 | pmc = | doi = 10.1006/bbrc.1999.1440 }}
3. ^{{cite journal |vauthors=Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR | title = A new nomenclature for IL-1-family genes | journal = Trends Immunol | volume = 22 | issue = 10 | pages = 536–7 |date=Sep 2001 | pmid = 11574262 | pmc = | doi =10.1016/S1471-4906(01)02040-3 }}
4. ^{{cite web | title = Entrez Gene: IL36RN interleukin 36 receptor antagonist| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26525| accessdate = }}
5. ^{{cite journal|last1=Towne|first1=JE|last2=Garka|first2=KE|last3=Renshaw|first3=BR|last4=Virca|first4=GD|last5=Sims|first5=JE|title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.|journal=The Journal of Biological Chemistry|date=2 April 2004|volume=279|issue=14|pages=13677–88|doi=10.1074/jbc.M400117200|pmid=14734551}}
6. ^{{cite journal|last1=Navarini|first1=AA|last2=Valeyrie-Allanore|first2=L|last3=Setta-Kaffetzi|first3=N|last4=Barker|first4=JN|last5=Capon|first5=F|last6=Creamer|first6=D|last7=Roujeau|first7=JC|last8=Sekula|first8=P|last9=Simpson|first9=MA|last10=Trembath|first10=RC|last11=Mockenhaupt|first11=M|last12=Smith|first12=CH|title=Rare variations in IL36RN in severe adverse drug reactions manifesting as acute generalized exanthematous pustulosis.|journal=The Journal of Investigative Dermatology|date=July 2013|volume=133|issue=7|pages=1904–7|doi=10.1038/jid.2013.44|pmid=23358093}}
7. ^{{cite journal |last1=Macleod |first1=T |last2=Doble |first2=R |last3=McGonagle |first3=D |last4=Wasson |first4=CW |last5=Alase |first5=A |last6=Stacey |first6=M |last7=Wittmann |first7=M |title=Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist |journal=Scientific Reports |date=22 April 2016 |volume=6 |pages=24880 |doi=10.1038/srep24880 |pmid=27101808|pmc=4840362 }}
[7]==Further reading== {{refbegin | 2}}- {{cite journal |vauthors=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}
- {{cite journal | author=Nothwang HG |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13 |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 |name-list-format=vanc| author2=Strahm B | author3=Denich D | display-authors=3 | last4=Kübler | first4=Matthias | last5=Schwabe | first5=Jenny | last6=Gingrich | first6=Jeffrey C. | last7=Jauch | first7=Anna | last8=Cox | first8=Angela | last9=Nicklin | first9=Martin J.H. }}
- {{cite journal | author=Kumar S |title=Identification and initial characterization of four novel members of the interleukin-1 family |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=10.1074/jbc.275.14.10308 |name-list-format=vanc| author2=McDonnell PC | author3=Lehr R | display-authors=3 | last4=Tierney | first4=L | last5=Tzimas | first5=MN | last6=Griswold | first6=DE | last7=Capper | first7=EA | last8=Tal-Singer | first8=R | last9=Wells | first9=GI }}
- {{cite journal | author=Busfield SJ |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2 |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 |name-list-format=vanc| author2=Comrack CA | author3=Yu G | display-authors=3 | last4=Chickering | first4=T.W. | last5=Smutko | first5=J.S. | last6=Zhou | first6=H. | last7=Leiby | first7=K.R. | last8=Holmgren | first8=L.M. | last9=Gearing | first9=D.P. }}
- {{cite journal |vauthors=Mulero JJ, Nelken ST, Ford JE |title=Organization of the human interleukin-1 receptor antagonist gene IL1HY1 |journal=Immunogenetics |volume=51 |issue= 6 |pages= 425–8 |year= 2000 |pmid= 10866108 |doi=10.1007/s002510050640 }}
- {{cite journal | author=Barton JL |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S |name-list-format=vanc| author2=Herbst R | author3=Bosisio D | display-authors=3 | last4=Higgins | first4=Lee | last5=Nicklin | first5=Martin J. H. }}
- {{cite journal | author=Pan G |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 |name-list-format=vanc| author2=Risser P | author3=Mao W | display-authors=3 | last4=Baldwin | first4=DT | last5=Zhong | first5=AW | last6=Filvaroff | first6=E | last7=Yansura | first7=D | last8=Lewis | first8=L | last9=Eigenbrot | first9=C }}
- {{cite journal | author=Lin H |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 |name-list-format=vanc| author2=Ho AS | author3=Haley-Vicente D | display-authors=3 | last4=Zhang | first4=J | last5=Bernal-Fussell | first5=J | last6=Pace | first6=AM | last7=Hansen | first7=D | last8=Schweighofer | first8=K | last9=Mize | first9=NK }}
- {{cite journal | author=Debets R |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi= 10.4049/jimmunol.167.3.1440|name-list-format=vanc| author2=Timans JC | author3=Homey B | display-authors=3 | last4=Zurawski | first4=S | last5=Sana | first5=TR | last6=Lo | first6=S | last7=Wagner | first7=J | last8=Edwards | first8=G | last9=Clifford | first9=T }}
- {{cite journal | author=Tazi-Ahnini R |title=Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction |journal=Eur. J. Immunogenet. |volume=29 |issue= 1 |pages= 25–30 |year= 2002 |pmid= 11841485 |doi=10.1046/j.1365-2370.2002.00271.x |name-list-format=vanc| author2=Cox A | author3=McDonagh AJ | display-authors=3 | last4=Nicklin | first4=M. J. H. | last5=Di Giovine | first5=F. S. | last6=Timms | first6=J. M. | last7=Messenger | first7=A. G. | last8=Dimitropoulou | first8=P. | last9=Duff | first9=G. W. }}
- {{cite journal | author=Nicklin MJ |title=A sequence-based map of the nine genes of the human interleukin-1 cluster |journal=Genomics |volume=79 |issue= 5 |pages= 718–25 |year= 2002 |pmid= 11991722 |doi= 10.1006/geno.2002.6751 |name-list-format=vanc| author2=Barton JL | author3=Nguyen M | display-authors=3 | last4=Fitzgerald | first4=Michael G | last5=Duff | first5=Gordon W | last6=Kornman | first6=Ken }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-format=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}
- {{cite journal | author=Zee RY |title=IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation |journal=Atherosclerosis |volume=171 |issue= 2 |pages= 259–64 |year= 2004 |pmid= 14644395 |doi=10.1016/S0021-9150(03)00294-6 |name-list-format=vanc| author2=Fernandez-Ortiz A | author3=Macaya C | display-authors=3 | last4=Pintor | first4=Emilio | last5=Fernandez-Cruz | first5=Arturo | last6=Lindpaintner | first6=Klaus }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}
- {{cite journal | author=Colland F |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |name-list-format=vanc| author2=Jacq X | author3=Trouplin V | display-authors=3 | last4=Mougin | first4=C | last5=Groizeleau | first5=C | last6=Hamburger | first6=A | last7=Meil | first7=A | last8=Wojcik | first8=J | last9=Legrain | first9=P }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{refend}}{{PDB Gallery|geneid=26525}}{{Cytokines}}{{Interleukin receptor modulators}} 1 : Cytokine receptors |