| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[1][2] Function This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[2] Interactions PARD6B has been shown to interact with: - CDC42,[1][3][4]
- Protein kinase Mζ,[1]
- RAC1,[1] and
- RHOQ.[3][4]
References 1. ^1 2 3 {{cite journal | vauthors = Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H | title = Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C | journal = Genes Cells | volume = 6 | issue = 2 | pages = 107–19 | date = March 2001 | pmid = 11260256 | pmc = | doi = 10.1046/j.1365-2443.2001.00404.x }}
2. ^1 {{cite web | title = Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84612| accessdate = }}
3. ^1 {{cite journal | vauthors = Neudauer CL, Joberty G, Macara IG | title = PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 | journal = Biochem. Biophys. Res. Commun. | volume = 280 | issue = 2 | pages = 541–7 | date = January 2001 | pmid = 11162552 | doi = 10.1006/bbrc.2000.4160 }}
4. ^1 {{cite journal | vauthors = Joberty G, Petersen C, Gao L, Macara IG | title = The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 | journal = Nat. Cell Biol. | volume = 2 | issue = 8 | pages = 531–9 | date = August 2000 | pmid = 10934474 | doi = 10.1038/35019573 }}
Further reading {{Refbegin | 2}}- {{cite journal | vauthors = Joberty G, Petersen C, Gao L, Macara IG | title = The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 | journal = Nat. Cell Biol. | volume = 2 | issue = 8 | pages = 531–9 | year = 2000 | pmid = 10934474 | doi = 10.1038/35019573 }}
- {{cite journal | vauthors = Gao L, Macara IG, Joberty G | title = Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties | journal = Gene | volume = 294 | issue = 1–2 | pages = 99–107 | year = 2003 | pmid = 12234671 | doi = 10.1016/S0378-1119(02)00681-9 }}
- {{cite journal | vauthors = Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H | title = PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions | journal = Biochem. Biophys. Res. Commun. | volume = 299 | issue = 4 | pages = 641–6 | year = 2003 | pmid = 12459187 | doi = 10.1016/S0006-291X(02)02698-0 }}
- {{cite journal | vauthors = Hurd TW, Gao L, Roh MH, Macara IG, Margolis B | title = Direct interaction of two polarity complexes implicated in epithelial tight junction assembly | journal = Nat. Cell Biol. | volume = 5 | issue = 2 | pages = 137–42 | year = 2003 | pmid = 12545177 | doi = 10.1038/ncb923 }}
- {{cite journal | vauthors = Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S | title = Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity | journal = Curr. Biol. | volume = 13 | issue = 9 | pages = 734–43 | year = 2004 | pmid = 12725730 | doi = 10.1016/S0960-9822(03)00244-6 }}
- {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }}
- {{cite journal | vauthors = Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL | title = Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 5 | pages = 1339–44 | year = 2005 | pmid = 15677324 | pmc = 547886 | doi = 10.1073/pnas.0409578102 }}
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