“RNF11”的意思、由来-开放百科全书

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).^[3]

References

1. ^{{cite journal | vauthors = Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T | title = Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein | journal = Biochim. Biophys. Acta | volume = 1489 | issue = 2–3 | pages = 421–7 | date = December 1999 | pmid = 10673045 | pmc = | doi = 10.1016/s0167-4781(99)00190-6 }}
2. ^{{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res. | volume = 10 | issue = 5 | pages = 703–13 | date = August 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}
3. ^¹{{cite web | title = Entrez Gene: RNF11 ring finger protein 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26994| accessdate = }}
4. ^{{cite journal | vauthors = Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW | title = The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling | journal = EMBO J. | volume = 28 | issue = 5 | pages = 513–22 | date = March 2009 | pmid = 19131965 | pmc = 2657574 | doi = 10.1038/emboj.2008.285 }}
5. ^{{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8 | date = March 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}

Further reading

{{cite journal | vauthors = Burger A, Amemiya Y, Kitching R, Seth AK | title = Novel RING E3 ubiquitin ligases in breast cancer | journal = Neoplasia | volume = 8 | issue = 8 | pages = 689–95 | year = 2006 | pmid = 16925951 | pmc = 1601945 | doi = 10.1593/neo.06469 }}

{{cite journal | vauthors = Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S | title = Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 | journal = Biochem. J. | volume = 351 Pt 3 | issue = 3| pages = 557–65 | year = 2000 | pmid = 11042109 | pmc = 1221394 | doi = 10.1042/0264-6021:3510557 }}

{{cite journal | vauthors = Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M | title = Characterization of gene expression induced by RET with MEN2A or MEN2B mutation | journal = Am. J. Pathol. | volume = 161 | issue = 1 | pages = 249–56 | year = 2002 | pmid = 12107109 | pmc = 1850689 | doi = 10.1016/S0002-9440(10)64176-4 }}

{{cite journal | vauthors = Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A | title = The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases | journal = Biochim. Biophys. Acta | volume = 1639 | issue = 2 | pages = 104–12 | year = 2003 | pmid = 14559117 | doi = 10.1016/j.bbadis.2003.07.001 }}

{{cite journal | vauthors = Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A | title = The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase | journal = Br. J. Cancer | volume = 89 | issue = 8 | pages = 1538–44 | year = 2003 | pmid = 14562029 | pmc = 2394340 | doi = 10.1038/sj.bjc.6601301 }}

{{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8 | year = 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}

{{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}

{{cite journal | vauthors = Connor MK, Azmi PB, Subramaniam V, Li H, Seth A | title = Molecular characterization of ring finger protein 11 | journal = Mol. Cancer Res. | volume = 3 | issue = 8 | pages = 453–61 | year = 2005 | pmid = 16123141 | doi = 10.1158/1541-7786.MCR-04-0166 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

{{cite journal | vauthors = Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI | title = PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain | journal = J. Neuropathol. Exp. Neurol. | volume = 66 | issue = 10 | pages = 955–64 | year = 2007 | pmid = 17917589 | doi = 10.1097/nen.0b013e3181567f17 }}

Function

See also

Interactions

References

Further reading

External links