| 词条 | Rosenthal fiber |
| 释义 |
A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders. Associated conditionsIts presence is associated with either pilocytic astrocytoma[1] (more common) or Alexander's disease (a rare leukodystrophy). They are also seen in the context of fucosidosis. Pilocytic astrocytoma is the most common primitive tumor in pediatric patients. CompositionThe fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins. Their components include glial fibrillary acidic protein.[2] References1. ^{{Cite journal|vauthors=Wippold FJ, Perry A, Lennerz J |title=Neuropathology for the neuroradiologist: Rosenthal fibers |journal=AJNR Am J Neuroradiol |volume=27 |issue=5 |pages=958–61 |date=May 2006 |pmid=16687524 |doi= |url=http://www.ajnr.org/cgi/pmidlookup?view=long&pmid=16687524}} 2. ^{{Cite journal|vauthors=Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K |title=Fluoro-Jade: new fluorescent marker of Rosenthal fibers |journal=Neurosci. Lett. |volume=407 |issue=2 |pages=127–30 |date=October 2006 |pmid=16949206 |doi=10.1016/j.neulet.2006.08.014 |url=http://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00802-0}} External links
1 : Neuropathology |
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