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词条 RRM2
释义

  1. Function

  2. Interactive pathway map

  3. References

  4. Further reading

{{Infobox_gene}}Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene.[1][2]

Function

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini.[1]

Interactive pathway map

{{FluoropyrimidineActivity WP1601|highlight=RRM2}}

References

1. ^1 {{cite web | title = Entrez Gene: ribonucleotide reductase M2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6241| accessdate = }}
2. ^{{cite journal |vauthors=Pavloff N, Rivard D, Masson S, Shen SH, Mes-Masson AM | title = Sequence analysis of the large and small subunits of human ribonucleotide reductase | journal = DNA Seq. | volume = 2 | issue = 4 | pages = 227–34 | year = 1992 | pmid = 1627826 | doi = 10.3109/10425179209020807| url = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Lin ZP, Belcourt MF, Cory JG, Sartorelli AC |title=Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27030–8 |year= 2004 |pmid= 15096505 |doi= 10.1074/jbc.M402056200 }}
  • {{cite journal |vauthors=Zhang K, Hu S, Wu J, etal |title=Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis |journal=Mol. Cancer |volume=8 |issue= |pages= 11 |year= 2009 |pmid= 19250552 |pmc=2662784 |doi= 10.1186/1476-4598-8-11 }}
  • {{cite journal |vauthors=Cohen D, Adamovich Y, Reuven N, Shaul Y |title=Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene |journal=Hepatology |volume=51 |issue= 5 |pages= 1538–46 |year= 2010 |pmid= 20155784 |doi= 10.1002/hep.23519 }}
  • {{cite journal |vauthors=Ferrandina G, Mey V, Nannizzi S, etal |title=Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer |journal=Cancer Chemother. Pharmacol. |volume=65 |issue= 4 |pages= 679–86 |year= 2010 |pmid= 19639316 |doi= 10.1007/s00280-009-1073-y }}
  • {{cite journal |vauthors=Qiu W, Zhou B, Darwish D, etal |title=Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 428–34 |year= 2006 |pmid= 16376858 |doi= 10.1016/j.bbrc.2005.12.019 }}
  • {{cite journal |vauthors=Boukovinas I, Papadaki C, Mendez P, etal |title=Tumor BRCA1, RRM1 and RRM2 mRNA Expression Levels and Clinical Response to First-Line Gemcitabine plus Docetaxel in Non-Small-Cell Lung Cancer Patients |journal=PLoS ONE |volume=3 |issue= 11 |pages= e3695 |year= 2008 |pmid= 19002265 |pmc=2579656 |doi= 10.1371/journal.pone.0003695 |editor1-last=Ramqvist |editor1-first=Torbjorn }}
  • {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA|title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 }}
  • {{cite journal |vauthors=Duxbury MS, Whang EE |title=RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 1 |pages= 190–6 |year= 2007 |pmid= 17222798 |doi= 10.1016/j.bbrc.2006.12.177 }}
  • {{cite journal |vauthors=Attia S, Kolesar J, Mahoney MR, etal |title=A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas |journal=Invest New Drugs |volume=26 |issue= 4 |pages= 369–79 |year= 2008 |pmid= 18278438 |doi= 10.1007/s10637-008-9123-6 |pmc=4461052 }}
  • {{cite journal |vauthors=Couch FJ, Wang X, Bamlet WR, etal |title=Association of Mitotic Regulation Pathway Polymorphisms with Pancreatic Cancer Risk and Outcome |journal=Cancer Epidemiol. Biomarkers Prev. |volume=19 |issue= 1 |pages= 251–7 |year= 2010 |pmid= 20056645 |pmc=2805468 |doi= 10.1158/1055-9965.EPI-09-0629 }}
  • {{cite journal |vauthors=Réjiba S, Bigand C, Parmentier C, Hajri A |title=Gemcitabine-Based Chemogene Therapy for Pancreatic Cancer Using Ad-dCK::UMK GDEPT and TS/RR siRNA Strategies |journal=Neoplasia |volume=11 |issue= 7 |pages= 637–50 |year= 2009 |pmid= 19568409 |pmc=2697350 |doi= 10.1593/neo.81686}}
  • {{cite journal |vauthors=Kolesar J, Huang W, Eickhoff J, etal |title=Evaluation of mRNA by Q-RTPCR and Protein Expression by AQUA of the M2 Subunit of Ribonucleotide Reductase (RRM2) in Human Tumors |journal=Cancer Chemother. Pharmacol. |volume=64 |issue= 1 |pages= 79–86 |year= 2009 |pmid= 18941749 |doi= 10.1007/s00280-008-0845-0 |pmc=3043989 }}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
  • {{cite journal |vauthors=Liu X, Xue L, Yen Y |title=Redox property of ribonucleotide reductase small subunit M2 and p53R2 |journal=Methods Mol. Biol. |volume=477 |issue= |pages= 195–206 |year= 2008 |pmid= 19082948 |doi= 10.1007/978-1-60327-517-0_15 |series=Methods In Molecular Biology |isbn=978-1-60327-218-6 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |pmc=528928 |doi= 10.1101/gr.2596504 }}
  • {{cite journal |vauthors=Bourdon A, Minai L, Serre V, etal |title=Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion |journal=Nat. Genet. |volume=39 |issue= 6 |pages= 776–80 |year= 2007 |pmid= 17486094 |doi= 10.1038/ng2040 }}
  • {{cite journal |vauthors=Souglakos J, Boukovinas I, Taron M, etal |title=Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine |journal=Br. J. Cancer |volume=98 |issue= 10 |pages= 1710–5 |year= 2008 |pmid= 18414411 |pmc=2391126 |doi= 10.1038/sj.bjc.6604344 }}
  • {{cite journal |vauthors=Zhang YW, Jones TL, Martin SE, etal |title=Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response |journal=J. Biol. Chem. |volume=284 |issue= 27 |pages= 18085–95 |year= 2009 |pmid= 19416980 |pmc=2709352 |doi= 10.1074/jbc.M109.003020 }}
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1 : EC 1.17.4
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