Brent Hughes may refer to:

• Brent Hughes (ice hockey, born 1943), NHL player for LA Kings, Philadelphia Flyers, St. Louis Blues, Detroit Red Wings & Kansas City Scouts
• Brent Hughes (ice hockey, born 1966), NHL player for the Winnipeg Jets, Boston Bruins, Buffalo Sabres and New York Islanders

• Illinois Route 120
• Illinois Route 126
• Illinois Route 127
• Illinois Route 13
• Illinois Route 131
• Illinois Route 132
• Illinois Route 134
• Illinois Route 137
• Illinois Route 140
• Illinois Route 143
• Illinois Route 15
• Illinois Route 157
• Illinois Route 158
• Illinois Route 159
• Illinois Route 16
• Illinois Route 160
• Illinois Route 161
• Illinois Route 162
• Illinois Route 17
• Illinois Route 171
• Illinois Route 173
• Illinois Route 176
• Illinois Route 185
• Illinois Route 19
• Illinois Route 2