| 词条 | Eva Nogales |
| 释义 |
| name = Eva Nogales | image = | alt = | caption = | birth_name = | birth_date = | birth_place = Madrid, Spain | death_date = | death_place = | nationality = | other_names = | ethnicity = | citizenship = | education = | alma_mater = B.S., physics, Autonomous University of Madrid in 1988, Ph.D., University of Keele, 1992 | years_active = | employer = University of California, Berkeley, Howard Hughes Medical Institute, Synchrotron Radiation Source | organization = | occupation = Biophysicist, professor | known_for = The first to determine the atomic structure of tubulin by electron crystallography | spouse = Howard Padmore | children = Two children | awards = Early Career Award, American Society for Cell Biology (2005) Chabot Science Award for Excellence (2006) }} Eva Nogales (b. Madrid, Spain) is a biophysicist at the Lawrence Berkeley National Laboratory. She is Head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology at the University of California, Berkeley and a Howard Hughes Medical Institute investigator. Nogales is a pioneer in using electron microscopy for the structural and functional characterization of macromolecular complexes. She used electron crystallography to obtain the first structure of tubulin and identify the binding site of the important anti-cancer drug taxol. She is a leader in combining cryo-EM, computational image analysis and biochemical assays to gain insights into function and regulation of biological complexes and molecular machines.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2] Early life and educationEva Nogales obtained her B.S. degree in physics from the Autonomous University of Madrid in 1988. She later earned her Ph.D. from the University of Keele in 1992 while working at the Synchrotron Radiation Source under the supervision of Joan Bordas. CareerDuring her post-doctoral work in the laboratory of Ken Downing at Keele University, Eva Nogales was the first to determine the atomic structure of tubulin and the location of the taxol-binding site by electron crystallography.[3][4][5] She joined Lawrence Berkeley National Laboratory as a Staff Scientist in 1995 and became an Assistant Professor in the Department of Molecular and Cell Biology at the University of California, Berkeley in 1998. In 2000 she became an Investigator in the Howard Hughes Medical Institute. As cryo-EM techniques became more powerful[6], she became a leader in applying cryo-EM to the study of microtubule structure and function[7] and other large macromolecular assemblies such as eukaryotic transcription and translation initiation complexes[8][9] and telomerase.[10] Awards
Personal lifeNogales is married to Howard Padmore and they have two children. References1. ^{{Cite news|url=https://www.mdtmag.com/news/2016/12/how-see-living-machines|title=How to See Living Machines|date=2016-12-07|work=Medical Design Technology|access-date=2018-02-03}} 2. ^{{Cite web|url=https://www.hhmi.org/scientists/eva-nogales|title=Eva Nogales|website=HHMI.org|language=en|access-date=2019-03-23}} 3. ^{{Cite journal|last=Nogales|first=E.|last2=Wolf|first2=S. G.|last3=Khan|first3=I. A.|last4=Ludueña|first4=R. F.|last5=Downing|first5=K. H.|date=1995-06-01|title=Structure of tubulin at 6.5 A and location of the taxol-binding site|url=https://www.ncbi.nlm.nih.gov/pubmed/7760939|journal=Nature|volume=375|issue=6530|pages=424–427|doi=10.1038/375424a0|issn=0028-0836|pmid=7760939}} 4. ^Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature, 391, 199-203. 5. ^{{Cite journal|last=Nogales|first=E.|last2=Whittaker|first2=M.|last3=Milligan|first3=R. A.|last4=Downing|first4=K. H.|date=1999-01-08|title=High-resolution model of the microtubule|url=https://www.ncbi.nlm.nih.gov/pubmed/9989499|journal=Cell|volume=96|issue=1|pages=79–88|issn=0092-8674|pmid=9989499}} 6. ^{{Cite journal|last=Callaway|first=Ewen|date=2015-09-10|title=The revolution will not be crystallized: a new method sweeps through structural biology|url=https://www.ncbi.nlm.nih.gov/pubmed/26354465|journal=Nature|volume=525|issue=7568|pages=172–174|doi=10.1038/525172a|issn=1476-4687|pmid=26354465}} 7. ^{{Cite journal|last=Downing|first=Kenneth H.|last2=Nogales|first2=Eva|date=2010|title=Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors|url=https://www.ncbi.nlm.nih.gov/pubmed/20888472|journal=Methods in Enzymology|volume=483|pages=121–142|doi=10.1016/S0076-6879(10)83006-X|issn=1557-7988|pmc=4165512|pmid=20888472|via=}} 8. ^Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell, 152(1):120-131. 9. ^{{Cite web|url=https://www.genengnews.com/news/stop-motion-view-of-dna-binding-complex-may-animate-drug-discovery/|title=Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery|date=2018-11-20|website=GEN - Genetic Engineering and Biotechnology News|language=en-US|access-date=2019-03-23}} 10. ^{{Cite web|url=https://www.technologynetworks.com/drug-discovery/articles/the-3d-structure-of-telomerase-uncovering-its-role-in-human-disease-300278|title=The 3D Structure of Telomerase: Uncovering Its Role in Human Disease|website=Drug Discovery from Technology Networks|language=en|access-date=2019-03-23}} 11. ^{{Cite web|url=https://www.ascb.org/award/early-career-life-scientist-award/|title=Early Career Life Scientist Award|website=ASCB|language=en-US|access-date=2019-03-23}} 12. ^{{Cite web|url=http://www.eurekalert.org/pub_releases/2015-02/tps-atw020415.php|title=Announcing the winners of the 2015 Protein Society Awards|website=EurekAlert!|language=en|access-date=2019-03-23}} 13. ^{{Cite news|url=http://www.dailycal.org/2016/04/22/9-campus-faculty-selected-membership-american-academy-arts-sciences/|title=9 campus faculty selected for membership in American Academy of Arts and Sciences {{!}} The Daily Californian|date=2016-04-22|work=The Daily Californian|access-date=2018-02-03|language=en-US}} 14. ^{{Cite web|url=https://www.ascb.org/award/women-in-cell-biology-awards/|title=Women in Cell Biology Awards|website=ASCB|language=en-US|access-date=2019-03-23}} 15. ^{{Cite web|url=http://biosciences.lbl.gov/2019/03/07/nogales-receives-2019-grimwade-medal/|title=Nogales Receives 2019 Grimwade Medal|date=2019-03-07|website=Biosciences Area|language=en-US|access-date=2019-03-23}} External links
10 : Howard Hughes Medical Investigators|Living people|Molecular biologists|Spanish biophysicists|Spanish emigrants to the United States|University of California, Berkeley faculty|Women biologists|Year of birth missing (living people)|American women scientists|21st-century women scientists |
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