| 词条 | Lofendazam |
| 释义 |
| verifiedrevid = 447931436 | IUPAC_name = 8-chloro-1-phenyl-1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one | image = Lofendazam.svg | width = 180 | tradename = | legal_status = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 29176-29-2 | ATC_prefix = none | PubChem = 71709 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 64759 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = V7O53S50SN | C=15 | H=13 | Cl=1 | N=2 | O=1 | molecular_weight = 272.73 | smiles = Clc3ccc1c(N(C(=O)CCN1)c2ccccc2)c3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C15H13ClN2O/c16-11-6-7-13-14(10-11)18(15(19)8-9-17-13)12-4-2-1-3-5-12/h1-7,10,17H,8-9H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IUJQOUHDFKALCY-UHFFFAOYSA-N }}Lofendazam[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. [2][3] Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[4] See also
References1. ^DE Patent 1929656 {{Benzodiazepines}}{{GABAAR PAMs}}2. ^Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Liebigs Annalen der Chemie, 1995. (10):1861-1869. 3. ^Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Organic Magnetic Resonance, 1981. 15(4):394-398 4. ^J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. {{ISBN|978-3-540-58961-7}} 4 : Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Lactams |
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