| 词条 | Ertapenem |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 461095141 | IUPAC_name = (4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl] pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7- oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | image = Ertapenem Formula V.1.svg | tradename = Invanz | Drugs.com = {{drugs.com|monograph|invanz}} | pregnancy_AU = B3 | pregnancy_US = B | licence_EU = yes | legal_status = Rx-only | routes_of_administration = Intramuscular, intravenous | bioavailability = 90% (intramuscular) | protein_bound = Inversely proportional to concentration; 85 to 95% | metabolism = Minor hydrolysis of beta-lactam ring, CYP not involved | elimination_half-life = 4 hours | excretion = Renal (80%) and fecal (10%) | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 153832-46-3 | ATC_prefix = J01 | ATC_suffix = DH03 | PubChem = 150610 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00303 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 132758 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = G32F6EID2H | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D04049 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 404903 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1359 | C=22 | H=25 | N=3 | O=7 | S=1 | molecular_weight = 475.516 g/mol | smiles = O=C(O)c1cc(ccc1)NC(=O)[C@H]4NC[C@@H](S\\C3=C(\2C(=O)[C@H]([C@H](O)C)[C@H]2[C@H]3C)C(=O)O)C4 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/t9-,10-,13+,14+,15-,16-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = JUZNIMUFDBIJCM-ANEDZVCMSA-N }}Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz.[1] References1. ^{{cite journal |vauthors=Papp-Wallace KM, Endimiani A, Taracila MA, Bonomo RA |title=Carbapenems: past, present, and future |journal=Antimicrob. Agents Chemother. |volume=55 |issue=11 |pages=4943–60 | date=November 2011 |pmid=21859938 |pmc=3195018 |doi=10.1128/AAC.00296-11 |url=}} {{CephalosporinAntiBiotics}}{{Merck&Co}} 4 : Carbapenem antibiotics|Benzoic acids|Anilides|Pyrrolidines |
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