| 词条 | Hamilton O. Smith |
| 释义 |
|name = Hamilton O. Smith |image = Hamilton Smith, 2.jpg |caption = Hamilton O. Smith (2011) (Photo: Jane Gitschier) |birth_date = {{birth date and age|1931|8|23}} |birth_place = New York City, New York |death_date = |death_place = |residence = |citizenship = |nationality = United States |ethnicity = |field = Photography |work_institutions = |alma_mater = University of California, Berkeley, BA Johns Hopkins School of Medicine, MD |doctoral_advisor = |doctoral_students = |known_for = Restriction enzymes |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |awards = Nobel Prize in Physiology or Medicine in 1978 |religion = |footnotes = |signature = }}Hamilton Othanel Smith (born August 23, 1931) is an American microbiologist and Nobel laureate.[1][2][3][4][5][6] Smith was born on August 23, 1931, and graduated from University Laboratory High School of Urbana, Illinois. He attended the University of Illinois at Urbana-Champaign, but in 1950 transferred to the University of California, Berkeley, where he earned his B.A. in Mathematics in 1952 . He received his medical degree from Johns Hopkins University in 1956. In 1975, he was awarded a Guggenheim Fellowship he spent at the University of Zurich. In 1970, Smith and Kent W. Wilcox discovered the first type II restriction enzyme,[7] that is now called as HindII.[1] Smith went on to discover DNA methylases that constitute the other half of the bacterial host restriction and modification systems, as hypothesized by Werner Arber of Switzerland.[1] He was awarded the Nobel Prize in Physiology or Medicine in 1978 for discovering type II restriction enzymes with Werner Arber and Daniel Nathans as co-recipients. He later became a leading figure in the nascent field of genomics, when in 1995 he and a team at The Institute for Genomic Research sequenced the first bacterial genome, that of Haemophilus influenzae.[8] H. influenza was the same organism in which Smith had discovered restriction enzymes in the late 1960s. He subsequently played a key role in the sequencing of many of the early genomes at The Institute for Genomic Research, and in the assembly of the human genome at Celera Genomics, which he joined when it was founded in 1998. More recently, he has directed a team at the J. Craig Venter Institute that works towards creating a partially synthetic bacterium, Mycoplasma laboratorium. In 2003 the same group synthetically assembled the genome of a virus, Phi X 174 bacteriophage. Currently, Smith is scientific director of privately held Synthetic Genomics, which was founded in 2005 by Craig Venter to continue this work. Currently, Synthetic Genomics is working to produce biofuels on an industrial-scale using recombinant algae and other microorganisms.[9] ReferencesThis article incorporates CC-BY-2.5 text from the reference[1] 1. ^1 2 3 {{Cite journal | last1 = Gitschier | first1 = J. | title = A Half-Century of Inspiration: An Interview with Hamilton Smith | doi = 10.1371/journal.pgen.1002466 | journal = PLoS Genetics| volume = 8 | issue = 1 | pages = e1002466 | year = 2012 | pmid = 22253610| pmc = 3257296}} 2. ^{{Cite journal | last1 = Raju | first1 = T. N. | title = The Nobel Chronicles | doi = 10.1016/S0140-6736(05)76606-X | journal = The Lancet| volume = 354 | issue = 9189 | page = 1567| year = 1999 | pmid = 10551539| pmc = }} 3. ^{{Cite journal | last1 = Shampo | first1 = M. A. | last2 = Kyle | first2 = R. A. | title = Hamilton Smith--Nobel Prize winner in medicine or physiology | journal = Mayo Clinic Proceedings| publisher=Elsevier| volume = 70 | issue = 6 | pages = 540 | year = 1995 | pmid = 7776712 | doi=10.1016/s0025-6196(11)64310-3}} 4. ^{{Cite journal | last1 = Berg | first1 = K. | title = The Nobel prize in physiology and medicine 1978. Nobel prize to a controversial research field | journal = Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke | volume = 98 | issue = 34–36 | pages = 1741–1742 | year = 1978 | pmid = 725894}} 5. ^{{Cite journal | doi = 10.1001/jama.240.20.2137 | title = Molecular genetics takes Nobel Prize | journal = JAMA: the Journal of the American Medical Association| publisher=American Medical Association| volume = 240 | issue = 20 | pages = 2137 | year = 1978 | pmid = | pmc = }} 6. ^{{Cite journal | doi = 10.1038/275684a0 | title = Brazil learns its ecological lessons–the hard way | journal = Nature| volume = 275 | issue = 5682 | pages = 689–90 | year = 1978 | pmid = 360075| pmc = | bibcode = 1978Natur.275..684.}} 7. ^{{Cite journal | author = Smith H, Wilcox KW | title = A Restriction enzyme from Hemophilus influenzae *1I. Purification and general properties | journal = Journal of Molecular Biology | volume = 51 | issue = 2 | pages = 379–391 | year = 1970 | pmid = 5312500 | doi = 10.1016/0022-2836(70)90149-X}} 8. ^{{cite journal|pmid=1330118|year=1992|author1=Smith|first1=H. O.|title=A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. 1970|journal=Biotechnology (Reading, Mass.)|volume=24|pages=38–50|last2=Wilcox|first2=K. W.}} 9. ^{{cite web|url=http://www.xconomy.com/san-diego/2009/06/04/craig-venter-has-algae-biofuel-in-synthetic-genomics-pipeline/|title=Craig Venter Has Algae Biofuel in Synthetic Genomics' Pipeline - Xconomy|work=Xconomy}} Further reading
|last=Lagerkvist |first=U |authorlink= |date=October 1978 |title=To split a gene |journal=Läkartidningen |volume=75 |issue=43 |language=Swedish |pages=3892–4 | publisher = | location = | pmid = 279742 | bibcode = | oclc =| id = | url = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = External links{{Commons category|Hamilton Othanel Smith}}
14 : American microbiologists|Members of the United States National Academy of Sciences|21st-century American biologists|Phage workers|Nobel laureates in Physiology or Medicine|American Nobel laureates|University of California, Berkeley alumni|Johns Hopkins University alumni|1931 births|Living people|University Laboratory High School (Urbana, Illinois) alumni|Biotechnologists|Guggenheim Fellows|Human Genome Project scientists |
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