| 词条 | CD300LF |
| 释义 |
CMRF35-like molecule 1, also known as CD300lf, is a protein that in humans is encoded by the CD300LF gene.[1][2] CD300lf belongs to the protein family of CD300. CD300lf is a membrane glycoprotein that contains an immonoglobulin domain and is expressed by myeloid and mast cells[3] of humans and other mammals. The protein functions in immunoregulation[4] but might also have a role in norovirus infections. CD300lf and norovirusesCD300lf has been shown to function as the primary receptor for murine norovirus in mice,[5][6] but it's still unknown whether human norovirus uses the same receptor in viral entry or not. Human and murine CD300lf proteins have about 59% identity in their immunoglobulin domains, with most of that variation occurring in parts of the protein called CDR3 and the CC’loop.[7] Murine norovirus binds to a cleft between these domains. The differences between murine and human CD300lf contribute to murine norovirus host species restriction, as incorporating murine CD300lf into human cells makes them susceptible to infection by the murine virus.[6] References1. ^{{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | display-authors = 6 | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }} 2. ^{{cite web | title = Entrez Gene: CD300LF CD300 molecule-like family member f| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146722| access-date = }} 3. ^{{Cite web|url=https://www.uniprot.org/uniprot/Q8TDQ1|title=CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene & protein|website=www.uniprot.org|access-date=2019-03-16}} 4. ^{{cite journal | vauthors = Voss OH, Tian L, Murakami Y, Coligan JE, Krzewski K | title = Emerging role of CD300 receptors in regulating myeloid cell efferocytosis | journal = Molecular & Cellular Oncology | volume = 2 | issue = 4 | pages = e964625 | date = 2015-10-02 | pmid = 27308512 | pmc = 4905414 | doi = 10.4161/23723548.2014.964625 }} 5. ^{{cite journal | vauthors = Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH | title = Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 115 | issue = 39 | pages = E9201-E9210 | date = September 2018 | pmid = 30194229 | pmc = 6166816 | doi = 10.1073/pnas.1805797115 }} 6. ^1 {{cite journal | vauthors = Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW | title = Discovery of a proteinaceous cellular receptor for a norovirus | journal = Science | volume = 353 | issue = 6302 | pages = 933–6 | date = August 2016 | pmid = 27540007 | pmc = 5484048 | doi = 10.1126/science.aaf1220 }} 7. ^{{cite journal | vauthors = Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N | title = The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1 | journal = Journal of Molecular Biology | volume = 367 | issue = 2 | pages = 310–8 | date = March 2007 | pmid = 17275839 | doi = 10.1016/j.jmb.2007.01.011 }} External links
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