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词条 FARP2
释义

  1. Model organisms

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.[1][2][3]

Model organisms

Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[6] Homozygous mutant animals had a thickened cerebral cortex and displayed abnormal hair shedding.[6]

Interactions

FARP2 has been shown to interact with PDZK1.[14]

References

1. ^{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | pmc = | doi = 10.1093/dnares/5.5.277 }}
2. ^{{cite journal | vauthors = Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M | title = A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling | journal = The Journal of Neuroscience | volume = 22 | issue = 19 | pages = 8504–13 | date = Oct 2002 | pmid = 12351724 | pmc = | doi = }}
3. ^{{cite web | title = Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9855| accessdate = }}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBPZ/salmonella-challenge/ |title=Salmonella infection data for Farp2 |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBPZ/citrobacter-challenge/ |title=Citrobacter infection data for Farp2 |publisher=Wellcome Trust Sanger Institute}}
6. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
7. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
8. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Farp2 |title=International Knockout Mouse Consortium}}
9. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4363551 |title=Mouse Genome Informatics}}
10. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
11. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
12. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
13. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}
14. ^{{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
  • {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
  • {{cite journal | vauthors = Miyamoto Y, Yamauchi J, Itoh H | title = Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK | journal = The Journal of Biological Chemistry | volume = 278 | issue = 32 | pages = 29890–900 | date = Aug 2003 | pmid = 12771149 | doi = 10.1074/jbc.M301559200 }}
  • {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
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1 : Genes mutated in mice
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