| 词条 | Glisoxepide |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 443837353 | ImageFile = Glisoxepide.svg | ImageSize = 275 | ImageFile1 = Glisoxepide molecule ball.png | ImageSize1 = 275 | IUPACName = N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl) | OtherNames = | Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 30380 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = H7SC0I332I | InChI = 1/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) | InChIKey = ZKUDBRCEOBOWLF-UHFFFAOYAG | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZKUDBRCEOBOWLF-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 25046-79-1 | PubChem = 32778 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2106618 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07118 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01289 | SMILES = O=C(NCCc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2)c3noc(c3)C }} | Section2 = {{Chembox Properties | Formula = C20H27N5O5S | MolarMass = 449.52388 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section6 = {{Chembox Pharmacology | ATCCode_prefix = A10 | ATCCode_suffix = BB11 }} |Section7={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylureas.[1] It belongs to second-generation sulfonylureas.[2] References1. ^{{cite journal |vauthors=Haupt E, Köberich W, Beyer J, Schöffling K |title=Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride and glisoxepide. I. Dose response relations and repeated administration in diabetic subjects |journal=Diabetologia |volume=7 |issue=6 |pages=449–54 |date=December 1971 |pmid=5004178 |doi=10.1007/bf01212061}} {{Oral hypoglycemics and insulin analogs}}{{Ion channel modulators}}{{gastrointestinal-drug-stub}}2. ^{{cite journal|last1=Loubatières|first1=A|last2=Ribes|first2=G|last3=Mariani|first3=MM|last4=Alric|first4=R|title=Pharmacological Comparison Between Tolbutamide and Two Second Generation Hypoglycemic Sulfonylureas (Glibenclamide and Glisoxepide)|journal=Acta diabetologica latina|volume=10|issue=2|pages=261–82|pmid=4200420|doi=10.1007/bf02590661|year=1973}} 6 : Potassium channel blockers|Azepanes|Carboxamides|Isoxazoles|Sulfonylureas|Ureas |
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