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词条 GPR124
释义

  1. Interactions

  2. References

  3. Further reading

{{Infobox_gene}}Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4][5][6]

Interactions

GPR124 has been shown to interact with DLG1.[7]

References

1. ^{{cite journal |vauthors=Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B | title = Cell surface tumor endothelial markers are conserved in mice and humans | journal = Cancer Res | volume = 61 | issue = 18 | pages = 6649–55 | date=September 2001| pmid = 11559528 | pmc = | doi = }}
2. ^{{cite journal |vauthors=Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB | title = There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini | journal = Biochem Biophys Res Commun | volume = 301 | issue = 3 | pages = 725–34 | date=February 2003| pmid = 12565841 | pmc = | doi =10.1016/S0006-291X(03)00026-3 }}
3. ^{{cite web | title = Entrez Gene: GPR124 G protein-coupled receptor 124| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25960| accessdate = }}
4. ^{{cite book |vauthors=Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}
5. ^{{cite journal |vauthors=Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Lett | volume = 531 | issue = 3 | pages = 407–14 |date=Nov 2002 | pmid = 12435584 | pmc = | doi =10.1016/S0014-5793(02)03574-3 }}
6. ^{{cite journal |vauthors=Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = EMBO J. | volume = 31 | issue = 6 | pages = 1364–78 |date=March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 | url = }}
7. ^{{cite journal |vauthors=Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y | title = Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein | journal = Oncogene | volume = 23 | issue = 22 | pages = 3889–97 |date=May 2004 | pmid = 15021905 | doi = 10.1038/sj.onc.1207495 }}

Further reading

{{refbegin}}
  • {{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
  • {{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 |display-authors=etal}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal |vauthors=Yamamoto Y, Irie K, Asada M |title=Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. |journal=Oncogene |volume=23 |issue= 22 |pages= 3889–97 |year= 2004 |pmid= 15021905 |doi= 10.1038/sj.onc.1207495 |display-authors=etal}}
  • {{cite journal |vauthors=Bjarnadóttir TK, Fredriksson R, Höglund PJ |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |display-authors=etal}}
  • {{cite journal |vauthors=Vallon M, Essler M |title=Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34179–88 |year= 2006 |pmid= 16982628 |doi= 10.1074/jbc.M605291200 }}
{{refend}}{{G protein-coupled receptors}}{{DEFAULTSORT:Gpr124}}{{transmembranereceptor-stub}}

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