“Methylthioadenosine nucleosidase”的意思、由来-开放百科全书

词条

Methylthioadenosine nucleosidase

释义

Structural studies
References

{{enzyme
| Name = methylthioadenosine nucleosidase
| EC_number = 3.2.2.16
| CAS_number = 50812-28-7
| IUBMB_EC_number = 3/2/2/16
| GO_code = 0008930
| image =
| width =
| caption =
}}

In enzymology, a methylthioadenosine nucleosidase ({{EC number|3.2.2.16}}) is an enzyme that catalyzes the chemical reaction

S-methyl-5'-thioadenosine + H₂O S-methyl-5-thio-D-ribose + adenine

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and H₂O, whereas its two products are S-methyl-5-thio-D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase. This enzyme participates in urea cycle and metabolism of amino groups and methionine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1NC1}}, {{PDB link|1NC3}}, {{PDB link|1Y6Q}}, {{PDB link|1Y6R}}, {{PDB link|1ZOS}}, and {{PDB link|2H8G}}.

References

{{cite journal | vauthors = Guranowski AB, Chiang PK, Cantoni GL | year = 1981 | title = 5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds | journal = Eur. J. Biochem. | volume = 114 | pages = 293–9 | pmid = 6783408 | doi = 10.1111/j.1432-1033.1981.tb05148.x | issue = 2 }}

2 : EC 3.2.2|Enzymes of known structure

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