| 词条 | Tessa Holyoake |
| 释义 |
|name =Tessa Laurie Holyoake | honorific_suffix = FRCP FRCPath FMedSci FRSE |image =Tessa Holyoake.jpg |image_size = |caption = Tessa Holyoake |alt = Photograph of Tessa Holyoake |birth_name = |birth_date = {{birth date|1963|3|17|df=yes}} |birth_place = Aberdeen, Scotland |death_date = {{death date and age|2017|8|30|1963|3|17|df=yes}} |death_place = Loch Tummel, Perthshire, Scotland |death_cause = breast cancer |nationality = Scottish |education = University of Glasgow |occupation = medical doctor, clinical scientist |years_active = –2017 |known_for = discovered stem cell of chronic myeloid leukaemia |relations = |work_institutions = University of Glasgow, Terry Fox Laboratory |specialism = oncology |research_field = chronic myeloid leukaemia }}Tessa Laurie Holyoake, {{Post-nominals|country=GBR|size=100%|sep=|FRCP|FRCPath|FMedSci|FRSE}} (17 March 1963 – 30 August 2017) was a Scottish haematology-oncology physician. She specialised in chronic myeloid leukaemia (CML), and discovered its stem cell. She was considered a world leading expert in leukaemia research.[1] Early life and educationTessa Holyoake was born in Aberdeen, Scotland on 17 March 1963. She attended Albyn School.[2] She studied medicine at the University of Glasgow, and graduated in 1985.[3] She completed her Ph.D at the Beatson Institute for Cancer Research in Glasgow.[4] CareerAfter specialising in oncology she worked from 1992 to 1996 as a clinical research fellow at the Cancer Research Campaign's laboratories in Glasgow. From 1996 to 1998 she worked at Terry Fox Laboratory in Vancouver and discovered that primitive stem cells in CML existed in a quiescent state, and therefore they did not respond to cell cycle-active agents like imatinib.[4] In 1999, she returned to Glasgow Royal Infirmary and in 2004 became Professor of Experimental Haematology, and Director of the Paul O'Gorman Leukaemia Research Centre.[3] In 2005, she first presented work showing that a combination of imatinib or dasatinib with a farnesyl transferase inhibitor was better at eradicating CML stem cells, which was published in 2007.[5] She developed drug treatment to target the abnormal CML stem cell, to go beyond the current lifelong tyrosine kinase inhibitor treatment. Awards
Personal lifeTessa Holyoake was married to Andy, a general practitioner, they had no children. She enjoyed mountain biking, hill walking, and kayaking, and fundraised for the Leukaemia Research Centre by cycling and climbing Munros.[10] On 31 August 2017 she died of metastatic breast cancer near Loch Tummel, Perthshire. The disease had been diagnosed in 2016.[3] References1. ^1 2 3 4 5 {{Cite web|url=https://www.gla.ac.uk/myglasgow/news/headline_546625_en.html|title=University of Glasgow - MyGlasgow - MyGlasgow News - Professor Tessa Holyoake|website=www.gla.ac.uk|language=en|access-date=2017-12-30}} 2. ^{{cite journal|doi=10.1136/bmj.j4224 |title=Tessa Holyoake |journal=BMJ |pages=j4224 |year=2017 |last1=Copland |first1=Mhairi |last2=Evans |first2=Jeff |last3=Samson |first3=Owen |last4=Drummond |first4=Mark }} 3. ^1 2 {{Cite journal |last=Geoff Watts |date=7 October 2017 |title=Obituary Tessa Laurie Holyoake |doi= 10.1016/S0140-6736(17)32557-6 |journal=The Lancet |volume=390 |issue=10103 |pages=1640}} 4. ^{{cite journal|author=Holyoake T, Jiang X, Eaves C, Eaves A|title=Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia|journal=Blood|volume=94|issue=6|pages=2056–64|pmid=10477735|year=1999}} 5. ^{{cite journal|author= Copland M, Pellicano F, Richmond L, Allan EK, Hamilton A, Lee FY, Weinmann R, Holyoake TL|title=BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors|journal=Blood|volume=111|issue=5|pages=2843–53|pmid=18156496|year=2008|doi=10.1182/blood-2007-09-112573}} 6. ^1 2 {{Cite journal |author=Eaves, Connie J.|date=20 September 2017 |title=Tessa Laurie Holyoake, (March 17, 1963 – August 30, 2017): Remembering a Life That Knew No Boundaries|journal=Experimental Hematology |doi=10.1016/j.exphem.2017.09.005}} 7. ^{{Cite web|url=http://www.saltiresociety.org.uk/awards/history-and-heritage/previous-years/2015/|title=2015 Andrew Fletcher of Saltoun Awards|last=|first=|date=|website=Saltire Society|archive-url=|archive-date=|dead-url=|access-date=2017-12-30}} 8. ^{{Cite news|url=http://scottishcancerfoundation.org.uk/news/inaugural-prize/|title=Major Award for Glasgow Cancer Specialist|date=2015-11-26|work=Scottish Cancer Foundation|access-date=2017-12-30|language=en-GB}} 9. ^1 {{Cite web|url=https://www.cml-foundation.org/index.php/about-us/prizes/859-the-2017-rowley-prize-is-awarded-to-professor-tessa-holyoake|title=iCMLf - The 2017 Rowley Prize is awarded to Professor Tessa Holyoake|last=Bockwinkel|first=Stefanie|website=www.cml-foundation.org|language=en-gb|access-date=2017-12-30}} 10. ^1 {{Cite news |date=7 September 2017 |title='A brilliant lady in every sense of the word' tributes paid to ground breaking University of Glasgow professor |url=http://www.glasgowlive.co.uk/news/glasgow-news/tributes-glasgow-professor-tessa-holyoake-13588415?service=responsive |newspaper=Glasgow live}} External links
14 : 2017 deaths|Scottish medical researchers|1963 births|Scottish women medical doctors|Scottish women academics|Scottish women scientists|Alumni of the University of Glasgow|Academics of the University of Glasgow|Fellows of the Royal Society of Edinburgh|Fellows of the Academy of Medical Sciences|Cancer researchers|British oncologists|Fellows of the Royal College of Physicians|Fellows of the Royal College of Pathologists |
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