| 释义 |
- See also
- References
Fixed-dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden. They may combine different classes of antiretrovirals (e.g., Atripla) or contain only a single class (e.g., Epzicom). Licensed fixed-dose combinations are shown in the table below. Some are complete single-tablet regimens for the management of HIV/AIDS (the drug is one pill taken once daily); the others must be combined with one or more additional pills to complete a regimen. | Brand name(s) | Ingredients (INN) | FDA approval date | Company | Single-tablet regimen? | | NRTIs / NtRTIs | NNRTI | INSTI | PI | PK enhancer | | Combivir | lamivudine
zidovudine | September 26, 1997 | ViiV Healthcare | No | Kaletra (developed countries)
Aluvia (developing countries) | lopinavir | ritonavir | September 15, 2000 | Abbott Laboratories | No | | Trizivir | abacavir
lamivudine
zidovudine | November 15, 2000 | ViiV Healthcare | Yes | Epzicom (US)
Kivexa (EU, RU) | abacavir
lamivudine | August 2, 2004 | ViiV Healthcare | No | | Generics, e.g., Triomune | lamivudine
stavudine | nevirapine | (not approved) | (many companies) | Yes | | Generics, e.g., Duovir-N | lamivudine
zidovudine
| nevirapine | (not approved) | (many companies) | Yes | | Truvada | emtricitabine
tenofovir disoproxil | August 2, 2004 | Gilead Sciences | No | | Atripla | emtricitabine
tenofovir disoproxil | efavirenz | July 12, 2006 | Gilead Sciences
Bristol-Myers Squibb | Yes | Complera (US)
Eviplera (EU, RU) | emtricitabine
tenofovir disoproxil | rilpivirine | August 10, 2011 | Gilead Sciences
Janssen Pharmaceutica | Yes | | Stribild | emtricitabine
tenofovir disoproxil | elvitegravir | cobicistat | August 27, 2012 | Gilead Sciences | Yes | | Triumeq | abacavir
lamivudine | dolutegravir | August 22, 2014 | ViiV Healthcare | Yes | | Evotaz | atazanavir | cobicistat | January 29, 2015 | Bristol-Myers Squibb | No | Prezcobix (US)
Rezolsta (EU) | darunavir | cobicistat | January 29, 2015 | Janssen Pharmaceutica | No | | Dutrebis | lamivudine | raltegravir | February 6, 2015 | Merck & Co. | No | | Genvoya | emtricitabine
tenofovir alafenamide | elvitegravir | cobicistat | November 5, 2015 | Gilead Sciences | Yes | | Odefsey | emtricitabine
tenofovir alafenamide | rilpivirine | March 1, 2016 | Gilead Sciences | Yes | | Descovy | emtricitabine
tenofovir alafenamide | April 4, 2016 | Gilead Sciences | No | | Juluca | rilpivirine | dolutegravir | November 21, 2017 | ViiV Healthcare | Yes | | Symfi, Symfi Lo | lamivudine
tenofovir disoproxil | efavirenz | February 5, 2018 (Symfi Lo)
March 22, 2018 (Symfi) | Mylan | Yes | | Biktarvy | emtricitabine
tenofovir alafenamide | bictegravir | February 7, 2018 | Gilead Sciences | Yes | | Cimduo | lamivudine
tenofovir disoproxil | February 28, 2018 | Mylan | No | | Symtuza | emtricitabine
tenofovir alafenamide | darunavir | cobicistat | July 17, 2018 | Janssen Pharmaceutica | Yes |
See also- Combination drug
- Pill burden
References{{HIVpharm}}{{DEFAULTSORT:Fixed-Dose Combination (Antiretroviral)}} 1 : Fixed dose combination (antiretroviral) |