El Barrio may refer to:

• The Spanish Harlem neighborhood of Manhattan, New York City
• Parts of East Los Angeles
• Wynwood neighborhood of Miami
• Gulfton neighborhood of Houston
• El Barrio (singer), a Spanish flamenco singer
• "El Barrio," a 2016 synthpop song by Eden xo
• A composition by Joe Henderson from the album Inner Urge

• Hexameter
• Hexameters
• Hexamethylene diamine
• Hexamethylene tetraamine
• Hexamethylene tetramine
• Hexamethylenetetramine
• Hexamethylene triperoxide diamine
• Hexamethylphosphoramide
• Hexamine fuel tablet
• Hexanchidae
• Hexanchiformes
• Hexane
• Hexanitrobenzene
• Hexanitromannitol
• Hexanitrostilbene
• Hexapawn
• Hexapla
• Hexaplex trunculus
• Hexaploid
• Hexaploidy
• Hexapod
• Hexaprotodon liberiensis
• Hexaspermum
• Hexastyle
• Hexateuch