1. Function

2. Interactions

3. References

4. Further reading

5. External links

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.^[2]

Interactions

MEIS1 has been shown to interact with PBX1^[3][4][5] and HOXA9.^[3][6]

References

Further reading

• {{cite journal | vauthors = Allen TD, Zhu YX, Hawley TS, Hawley RG | title = TALE homeoproteins as HOX11-interacting partners in T-cell leukemia | journal = Leukemia & Lymphoma | volume = 39 | issue = 3-4 | pages = 241–56 | date = Oct 2000 | pmid = 11342305 | doi = 10.3109/10428190009065824 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
• {{cite journal | vauthors = Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM | title = Identification of a conserved family of Meis1-related homeobox genes | journal = Genome Research | volume = 7 | issue = 2 | pages = 142–56 | date = Feb 1997 | pmid = 9049632 | doi = 10.1101/gr.7.2.142 }}
• {{cite journal | vauthors = Smith JE, Bollekens JA, Inghirami G, Takeshita K | title = Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene | journal = Genomics | volume = 43 | issue = 1 | pages = 99–103 | date = Jul 1997 | pmid = 9226379 | doi = 10.1006/geno.1997.4766 }}
• {{cite journal | vauthors = Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C | title = AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6448–58 | date = Nov 1997 | pmid = 9343407 | pmc = 232497 | doi = }}
• {{cite journal | vauthors = Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP | title = Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14553–8 | date = Dec 1997 | pmid = 9405651 | pmc = 25052 | doi = 10.1073/pnas.94.26.14553 }}
• {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
• {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }}
• {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = }}
• {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–61 | date = Sep 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
• {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = }}
• {{cite journal | vauthors = Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R | title = The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32 | journal = Genomics | volume = 71 | issue = 2 | pages = 214–21 | date = Jan 2001 | pmid = 11161815 | doi = 10.1006/geno.2000.6408 }}
• {{cite journal | vauthors = Wang Y, Yin L, Hillgartner FB | title = The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23838–48 | date = Jun 2001 | pmid = 11331288 | doi = 10.1074/jbc.M102166200 }}
• {{cite journal | vauthors = Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T | title = Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene | journal = Blood | volume = 101 | issue = 12 | pages = 4748–56 | date = Jun 2003 | pmid = 12609849 | doi = 10.1182/blood-2002-02-0380 }}
• {{cite journal | vauthors = Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK | title = Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization | journal = Molecular and Cellular Biology | volume = 24 | issue = 2 | pages = 617–28 | date = Jan 2004 | pmid = 14701735 | pmc = 343796 | doi = 10.1128/MCB.24.2.617-628.2004 }}
• {{cite journal | vauthors = Pineault N, Abramovich C, Ohta H, Humphries RK | title = Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1 | journal = Molecular and Cellular Biology | volume = 24 | issue = 5 | pages = 1907–17 | date = Mar 2004 | pmid = 14966272 | pmc = 350554 | doi = 10.1128/MCB.24.5.1907-1917.2004 }}

External links

• {{MeshName|MEIS1+protein,+human}}

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