Lyse may refer to:

• Lyse Abbey, a former Cistercian abbey in Norway
• Lyse, an alternative name of Lysebotn, Norway
• Lyse Energi, a Norwegian power company
• Łyse, Masovian Voivodeship, a village in east-central Poland
• Łyse, Podlaskie Voivodeship, a village in north-east Poland
• lyse is a verb referring to the process of lysis, the death of a cell by bursting
• Lyse (mythology), daughter of Thespius and Megamede in Greek mythology, who bore Heracles a son, Eumedes
• Lyse Doucet, Canadian journalist, presenter and correspondent for BBC World Service radio and BBC World television
• Lysine Exporter (LysE) Superfamily, classification of particular transport proteins

• Clear creek high school
• Clear Creek High School (League City, Texas)
• Clear Creek Independent School District
• Clear Creek ISD
• Clear Creek, Minnesota
• Clear Creek, MN
• Clear Creek (Sacramento River tributary)
• Clearcreek Township
• Clearcreek Township, Warren County, OH
• Clearcreek Township, Warren County, Ohio
• Clear Creek, WI
• Clear Creek, Wisconsin
• Clear cut
• Clearcut
• Clearcutting
• Clear-cutting
• Clear cutting
• Clearfield
• Clearfield County
• Clearfield County, PA
• Clearfield County, Pennsylvania
• Clearfield, IA
• Clearfield, Iowa
• Clearfield, PA
• Clearfield, Pennsylvania