By place

Macedonian Empire

• At Maracanda, Alexander murders Cleitus, one of his most trusted commanders, friend and foster-brother, in a drunken quarrel; but his excessive display of remorse leads the army to pass a decree convicting Cleitus posthumously of treason.
• Spitamenes raises all Sogdiana in revolt behind him, bringing in the Massagetae, a people of the Scythian confederacy. He besieges the Macedonian garrison in Maracanda. Alexander the Great sends an army under the command of Pharnuches of Lycia which is promptly annihilated with a loss of more than 2,000 infantry and 300 cavalry.
• Understanding now the danger represented by his enemy, Alexander moves personally to relieve Maracanda, only to learn that Spitamenes has left Sogdiana. Spitamenes then attacks Bactra, from where he is repulsed with great difficulty by the satrap of Bactria, Artabazus of Phrygia.
• Alexander attacks Oxyartes and the remaining Bactrian barons who are holding out in the hills of Paraetacene (modern Tajikistan). The Macedonians seize the crag on which Oxyartes has his stronghold (the Sogdian Rock), and among the captives is his daughter, Roxana. In the reconciliation that follows the battle, Alexander marries Roxana. The rest of Oxyartes' opponents are either won over or crushed.
• December – Spitamenes is badly defeated by Alexander's general Coenus. At this point Spitamenes' allies, feeling the situation desperate, kill their leader and send his head as a gift to Alexander.