Crack-Up can refer to:

• The Crack-Up, a 1945 collection of essays by F. Scott Fitzgerald
• Crack-Up (1936 film), an American movie
• Crack-Up (1946 film), an American movie
• Crack-Up (album), 2017 album by Fleet Foxes

• The Chronic 2
• The Chronic 3
• The Chronic (Intro)
• The Chronic Intro
• The Chronicle and Sentinel-Mist
• The Chronicle (disambiguation)
• The Chronicle (Duke University)
• The Chronicle-Herald
• The Chronicle (North Central College)
• The Chronicle of Britain
• The Chronicle of Seert
• The Chronicle of Siirt
• The Chronicles (E.S.G. album)
• The Chronicles of Amber (omnibus)
• The Chronicles of Ancient Darkness
• The Chronicles of Avantia
• The Chronicles of Barnia
• The Chronicles of Corum
• The Chronicles of Eden
• The Chronicles of England, Scotland, and Ireland
• The Chronicles of Galen Sword
• The Chronicles of Hugh de Singleton
• The Chronicles of Lucius Leffing
• The Chronicles of Master Li and Number Ten Ox
• The Chronicles of Meap