ESDI may refer to:

• Engineering Synthesis Design Inc
• Enhanced Small Disk Interface
• Escola Superior de Desenho Industrial - The industrial and graphic design branch of Rio de Janeiro State University in Brazil
• European Security and Defence Identity.

• Locations in Australia with an English name
• Locations in Barbados with an English name
• Locations in Canada with an English name
• Locations in Florence
• Locations in Sri Lanka with a British name
• Locations in the United States with an English place name
• Locations in the United States with a Scottish name
• Locations in the United States with a Welsh name
• Locations in the world with an English name
• Location (song)
• Locator (song)
• Loca (Álvaro Soler song)
• Loca (Álvaro Soler Song)
• Loccenius
• L'occident
• L 'Occitane
• LOC Classification
• Loceff, Michael
• Loce, Georgia
• Loc-Eguiner Parish close
• Lochaber Loch
• Lochaber, South Australia
• Loch a' Bhainne
• Loch a' Bhraoin
• Loch Achanalt