| 词条 | Atrolysin E |
| 释义 |
| Name = Atrolysin E | EC_number = 3.4.24.44 | CAS_number = 172306-51-3 | IUBMB_EC_number = 3/4/24/44 | GO_code = | image = | width = | caption = }}Atrolysin E ({{EC number|3.4.24.44}}, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction Cleavage of Asn3-Gln, Ser9-His and Ala14-Leu bonds in insulin B chain and Tyr14-Gln and Thr8-Ser in A chain. Cleaves type IV collagen at Ala73-Gln in alpha1(IV) and at Gly7-Leu in alpha2(IV) This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox). References1. ^{{cite journal | title = Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e |author1 = Bjarnason, J.B. |author2 =Tu, A.T. |journal = Biochemistry |year = 1978 |volume = 17 |pages = 3395–3404 |pmid = 210790 |doi=10.1021/bi00609a033}} 2. ^{{cite journal | title = Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox) |author1 = Bjarnason, J.B. |author2 =Fox, J.W. |journal = Biochemistry |year = 1983 |volume = 22 |pages = 3770–3778 |pmid = 6351911 |issue=16 |doi=10.1021/bi00285a009}} 3. ^{{cite journal | title = Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen |author1 = Baramova, E.N. |author2 =Shannon, J.D. |author3 =Bjarnason, J.B. |author4 =Fox, J.W. |journal = Matrix |year = 1990 |volume = 10 |pages = 91–97 |pmid = 2374521 |issue=2 |doi=10.1016/s0934-8832(11)80175-7}} External links
1 : EC 3.4.24 |
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