| 词条 | Herbert C. Brown |
| 释义 |
|name = Herbert C. Brown |image = Herbert_C._Brown.png |birth_name=Herbert Brovarnik |birth_date = May 22, 1912 |birth_place = London, England, UK |death_date = {{death date and age|2004|12|19|1912|05|22}} |death_place = Lafayette, Indiana, US |nationality = American |field = Chemistry |work_institutions = University of Chicago, Purdue University |alma_mater = University of Chicago |doctoral_advisor = Hermann Irving Schlesinger |doctoral_students = |known_for = Organoboranes |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = Akira Suzuki Ei-ichi Negishi | prizes = National Medal of Science {{small|(1969)}} Elliott Cresson Medal {{small|(1978)}} Nobel Prize for Chemistry {{small|(1979)}} Priestley Medal {{small|(1981)}} Perkin Medal {{small|(1982)}}[1] AIC Gold Medal {{small|(1985)}} NAS Award in Chemical Sciences (1987) |religion = |footnotes = |spouse=Sarah Baylen (1937–2004; his death; 1 child) }} Herbert Charles Brown (May 22, 1912 – December 19, 2004) was an English-born American chemist and recipient of the 1979 Nobel Prize in Chemistry for his work with organoboranes. Life and careerBrown was born Herbert Brovarnik in London, to Ukrainian Jewish immigrants from Zhitomir, Pearl (née Gorinstein) and Charles Brovarnik, a hardware store manager and carpenter.[2] His family moved to Chicago in June 1914, when he was two years old.[3][4] Brown attended Crane Junior College in Chicago, where he met Sarah Baylen, whom he would later marry. The college was under threat of closing, and Brown and Baylen transferred to Wright Junior College.[4] In 1935 he left Wright Junior College and that autumn entered the University of Chicago, completed two years of studies in three quarters, and earned a B.S. in 1936.[3] That same year, he became a naturalized United States citizen.[5] On February 6, 1937, Brown married Baylen, the person he credits with making him interested in hydrides of boron, a topic related to the work in which he, together with Georg Wittig, won the Nobel prize in Chemistry in 1979.[3] Two years after starting graduate studies, he earned a Ph.D. in 1938, also from the University of Chicago. Unable to find a position in industry, he decided to accept a postdoctoral position. This became the beginning of his academic career. He became an instructor at the University of Chicago in 1939, and held the position for four years before moving to Wayne University in Detroit as an assistant professor. In 1946, he was promoted to associate professor. He became a professor of inorganic chemistry at Purdue University in 1947[6] and joined the Beta Nu Chapter of Alpha Chi Sigma there in 1960.[7] He held the position of Professor Emeritus from 1978 until his death in 2004.[3] The Herbert C. Brown Laboratory of Chemistry was named after him on Purdue University's campus. He was an honorary member of the International Academy of Science. During World War II, while working with Hermann Irving Schlesinger, Brown discovered a method for producing sodium borohydride (NaBH4), which can be used to produce boranes, compounds of boron and hydrogen. His work led to the discovery of the first general method for producing asymmetric pure enantiomers. The elements found as initials of his name H, C and B were his working field. In 1969, he was awarded the National Medal of Science.[8] Brown was quick to credit his wife Sarah with supporting him and allowing him to focus on creative efforts by handling finances, maintaining the house and yard, etc. According to Brown, after receiving the Nobel prize in Stockholm, he carried the medal and she carried the US$100,000 award. He was inducted into the Alpha Chi Sigma Hall of Fame in 2000.[9] He died December 19, 2004, at a hospital in Lafayette, Indiana after a heart attack. His wife died May 29, 2005, aged 89. ResearchIn 1939, Brown became the research assistant in Schlesinger's laboratory. In 1940, they began to research volatile, low molecular weight uranium compounds for the National Defense Research Committee. Brown and Schlesinger successfully synthesized volatile uranium(IV) borohydride, which had a molecular weight of 298. The laboratory was asked to provide a large amount of the product for testing, but diborane was in short supply. They discovered that it could be formed by reacting lithium hydride with boron trifluoride in ethyl ether, allowing them to produce the chemical in larger quantities. This success was met with several new problems. Lithium hydride was also in short supply, so Brown and Schlesinger needed to find a procedure that would allow them to use sodium hydride instead. They discovered that sodium hydride and methyl borate reacted to produce sodium trimethoxyborohydride, which was viable as a substitute for the lithium hydride.[10] Soon they were informed that there was no longer a need for uranium borohydride, but it appeared that sodium borohydride could be useful in generating hydrogen. They began to look for a cheaper synthesis and discovered that adding methyl borate to sodium hydride at 250° produced sodium borohydride and sodium methoxide. When acetone was used in an attempt to separate the two products, it was discovered that sodium borohydride reduced the acetone.[10] Sodium borohydride is a mild reducing agent that works well in reducing aldehydes, ketones, and acid chlorides. Lithium aluminum hydride is a much more powerful reducing agent that can reduce almost any functional group. When Brown moved to Purdue University in 1947, he worked to find stronger borohydrides and milder aluminum hydrides that would provide a spectrum of reducing agents. The team of researchers at Purdue discovered that changing the metal ion of the borohydride to lithium, magnesium, or aluminum increases the reducing ability. They also found that introducing alkoxy substituents to the aluminum hydride decreases the reducing ability. They successfully developed a full spectrum of reducing agents.[10] See also
References1. ^{{cite web|title=SCI Perkin Medal|url=https://www.sciencehistory.org/sci-perkin-medal|website=Science History Institute|accessdate=24 March 2018|deadurl=no|archiveurl=https://web.archive.org/web/20180202130738/https://www.sciencehistory.org/sci-perkin-medal|archivedate=2 February 2018|df=|date=2016-05-31}} 2. ^{{cite book|url=https://books.google.com/books?id=jEy67gEvIuMC&pg=PA605|title=Nobel Laureates in Chemistry, 1901-1992|first=James K.|last=Laylin|date=30 October 1993|publisher=Chemical Heritage Foundation|via=Google Books|isbn=9780841226906}} 3. ^1 2 3 {{cite web | author = Wilhelm Odelberg | title = Herbert C. Brown: The Nobel Prize in Chemistry 1979 | work = Les Prix Nobel | publisher = Nobel Foundation | year = 1979 | url = http://nobelprize.org/nobel_prizes/chemistry/laureates/1979/brown-autobio.html | accessdate = 2007-08-27 | deadurl = no | archiveurl = https://web.archive.org/web/20070819114912/http://nobelprize.org/nobel_prizes/chemistry/laureates/1979/brown-autobio.html | archivedate = 2007-08-19 | df = }} 4. ^1 {{cite web | last = Negishi | first = Ei-Ichi | title = Herbert Charles Brown | publisher = National Academy of Sciences | date = 2008 | url = http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/brown-herbert-c.pdf | deadurl = no | archiveurl = https://web.archive.org/web/20150910021245/http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/brown-herbert-c.pdf | archivedate = 2015-09-10 | df = }} 5. ^{{cite web | title = Herbert C. Brown | work = Notable Names Database | publisher = Soylent Communications | url = http://www.nndb.com/people/625/000100325/ | accessdate = 2007-08-27 | deadurl = no | archiveurl = https://web.archive.org/web/20070930072227/http://www.nndb.com/people/625/000100325/ | archivedate = 2007-09-30 | df = }} 6. ^{{cite web |title = Biography of Herbert C. Brown |publisher = Purdue University |year = 2001 |url = http://www.chem.purdue.edu/people/HCBrown/default.asp |accessdate = 2007-08-27 |deadurl = no |archiveurl = https://web.archive.org/web/20080326234703/http://www.chem.purdue.edu/people/HCBrown/default.asp |archivedate = 2008-03-26 |df = }} 7. ^{{cite web | title = Alpha Chi Sigma Hall of Fame | publisher = Alpha Chi Sigma Fraternity | url = http://www.alphachisigma.org/NetCommunity/Page.aspx?pid=268&srcid=273 | accessdate = 2008-01-07}} 8. ^{{cite web|url=https://www.nsf.gov/od/nms/recip_details.cfm?recip_id=59|title=The President's National Medal of Science: Recipient Details - NSF - National Science Foundation|author=|date=|website=www.nsf.gov|deadurl=no|archiveurl=https://web.archive.org/web/20121015220111/http://www.nsf.gov/od/nms/recip_details.cfm?recip_id=59|archivedate=2012-10-15|df=}} 9. ^{{cite web|url=https://www.alphachisigma.org/|title=Alpha Chi Sigma Fraternity|author=|date=|website=alphachisigma.org|deadurl=no|archiveurl=https://web.archive.org/web/20171207192148/https://www.alphachisigma.org/|archivedate=2017-12-07|df=}} 10. ^1 2 3 4 5 {{cite web |url=http://www.chem.purdue.edu/hcbrown/nobel.pdf |title=Archived copy |accessdate=2014-05-14 |deadurl=yes |archiveurl=https://web.archive.org/web/20140809033952/http://www.chem.purdue.edu/hcbrown/nobel.pdf |archivedate=2014-08-09 |df= }} 11. ^{{cite web|url=http://www.chem.ucla.edu/harding/IGOC/H/hydroboration_oxidation_reaction.html|title=Illustrated Glossary of Organic Chemistry - Hydroboration-oxidation reaction |author= |date= |website=www.chem.ucla.edu |deadurl=no|archiveurl=https://web.archive.org/web/20140515084824/http://www.chem.ucla.edu/harding/IGOC/H/hydroboration_oxidation_reaction.html|archivedate=2014-05-15|df=}} External links
19 : 1912 births|2004 deaths|English Jews|English people of Ukrainian-Jewish descent|English emigrants to the United States|American people of Ukrainian-Jewish descent|Jewish American scientists|Jewish chemists|Inorganic chemists|Stereochemists|People from London|Purdue University faculty|Wayne State University faculty|University of Chicago alumni|National Medal of Science laureates|Nobel laureates in Chemistry|American Nobel laureates|British Nobel laureates|Wilbur Wright College alumni |
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