Several ships of the Royal Navy have been named HMS Defence:

• {{HMS|Defence|1763}}, launched in 1763, fought in many battles in the American Revolutionary War, the French Revolutionary Wars and the Napoleonic Wars.
• {{HMS|Defence|1815}} was a 74-gun ship of the line, built in 1815 and broken up in 1857.
• {{HMS|Defence|1861}}, launched in 1861, was an ironclad scrapped in 1935.
• {{HMS|Defence|1907}}, launched in 1907, was an armoured cruiser sunk at the Battle of Jutland.
• Light cruiser Defence was launched in 1945 but work on her was suspended until 1954. In 1957 she was renamed {{HMS|Lion|C34|2}}.

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