| 词条 | Glycine reuptake inhibitor |
| 释义 |
A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). Examples of GRIs include bitopertin (RG1678), Org 24598, Org 25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and Org 25543 and N-arachidonylglycine, which are selective GlyT2 blockers.[1][2] Some weak and/or non-selective GlyT blockers include amoxapine and ethanol (alcohol).[3] See also
References1. ^{{cite journal |vauthors=Harsing LG, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P | title = Glycine transporter type-1 and its inhibitors | journal = Curr. Med. Chem. | volume = 13 | issue = 9 | pages = 1017–44 | year = 2006 | pmid = 16611082 | doi = 10.2174/092986706776360932 }} 2. ^{{cite journal |vauthors=Harvey RJ, Yee BK | title = Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain | journal = Nat Rev Drug Discov | volume = 12 | issue = 11 | pages = 866–85 |date=November 2013 | pmid = 24172334 | doi = 10.1038/nrd3893 }} 3. ^{{cite book|author1=Harald Sitte|author2=Michael Freissmuth|title=Neurotransmitter Transporters|url=https://books.google.com/books?id=CeZDAAAAQBAJ&pg=PA472|date=2 August 2006|publisher=Springer Science & Business Media|isbn=978-3-540-29784-0|pages=472–}} External links
1 : Glycine reuptake inhibitors |
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