| 词条 | Coenzyme M |
| 释义 |
| Watchedfields = | verifiedrevid = | Name = Coenzyme M | ImageFile = Coenzyme M (CoM).svg | ImageSize = | ImageFileR1 = | ImageFileR1_Ref = {{chemboximage|correct|}} | ImageSizeR1 = | ImageAltR1 = | ImageCaptionR1 = | ImageFileL2 = | ImageFileL2_Ref = {{chemboximage|correct|}} | ImageSizeL2 = | ImageAltL2 = | ImageCaptionL2 = | ImageFileR2 = | ImageFileR2_Ref = {{chemboximage|correct|}} | ImageSizeR2 = | ImageAltR2 = | ImageCaptionR2 = | IUPACName = 2-Sulfanylethanesulfonate | SystematicName = 2-Sulfanylethanesulfonate | OtherNames = 2-mercaptoethylsulfonate; 2-mercaptoethanesulfonate; coenzyme M anion; H-S-CoM; AC1L1HCY; 2-sulfanylethane-1-sulfonate; CTK8A8912 |Section1={{Chembox Identifiers | Abbreviations = | CASNo1 = 3375-50-6 | CASNo1_Comment = sulfonic acid form | CASNo2 = 40292-31-7 | CASNo2_Comment = sulfonate form | CASNo_Ref = {{cascite|correct|CAS}} | CASNoOther = | PubChem = 4077 | PubChem_Comment = | PubChem5 = | PubChem5_Comment = | PubChemOther = | ChemSpiderID = 3935 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Comment = | ChemSpiderID5 = | ChemSpiderIDOther = | EINECS = | EC_number = | UNNumber = | UNII = | UNII_Ref = {{fdacite|correct|FDA}} | DrugBank = | KEGG = | KEGG_Ref = {{keggcite|correct|kegg}} | MeSHName = | ChEBI = 58319 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEMBL = | ChEMBL_Ref = {{ebicite|correct|EBI}} | RTECS = | SMILES = [O-]S(=O)(=O)CCS | InChI = | StdInChI = 1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)/p-1 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZNEWHQLOPFWXOF-UHFFFAOYSA-M | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | Beilstein = | Gmelin = | 3DMet = |Section2={{Chembox Properties | C=2 | H=5 | O=3 | S=2 | MolarMass = | Appearance = | Density = | MeltingPt = | MeltingPt_notes = | BoilingPt = | BoilingPt_notes = | LogP = | VaporPressure = | HenryConstant = | AtmosphericOHRateConstant = | pKa = | pKb = | Solubility = | SolubleOther = | Solvent = |Section3={{Chembox Structure | CrystalStruct = | Coordination = | MolShape = |Section4={{Chembox Thermochemistry | DeltaHc = | DeltaHf = | Entropy = | HeatCapacity = |Section5={{Chembox Pharmacology | AdminRoutes = | Bioavail = | Metabolism = | HalfLife = | ProteinBound = | Excretion = | Legal_status = | Legal_US = | Legal_UK = | Legal_AU = | Legal_CA = | Pregnancy_category = | Pregnancy_AU = | Pregnancy_US = |Section6={{Chembox Explosive | ShockSens = | FrictionSens = | DetonationV = | REFactor = |Section7={{Chembox Hazards | ExternalSDS = | EUClass = | MainHazards = | NFPA-H = | NFPA-F = | NFPA-R = | NFPA-S = | RPhrases = | SPhrases = | RSPhrases = | FlashPt = | AutoignitionPt = | ExploLimits = | LD50 = | PEL = |Section8={{Chembox Related | OtherAnions = | OtherCations = | OtherFunction = | OtherFunction_label = | OtherCompounds = }} Coenzyme M is a coenzyme required for methyl-transfer reactions in the metabolism of methanogens.[1][2] The coenzyme is an anion with the formula {{chem|HSCH|2|CH|2|SO|3|-}}. It is named 2-mercaptoethanesulfonate and abbreviated HS–CoM. The cation is unimportant, but the sodium salt is most available. Mercaptoethanesulfonate contains both a thiol, which is the main site of reactivity, and a sulfonate group, which confers solubility in aqueous media. Biochemical roleThe coenzyme is the C1 donor in methanogenesis. It is converted to methyl-coenzyme M thioether, the thioether {{chem|CH|3|SCH|2|CH|2|SO|3|-}}, in the penultimate step to methane formation.[3] Methyl-coenzyme M reacts with coenzyme B, 7-thioheptanoylthreoninephosphate, to give a heterodisulfide, releasing methane: {{chem|CH|3|–S–CoM}} + HS–CoB → {{chem|CH|4}} + CoB–S–S–CoM This induction is catalyzed by the enzyme methyl-coenzyme M reductase, which restricts cofactor F430 as the prosthetic group. See also
References1. ^{{cite journal |vauthors=Balch WE, Wolfe RS |title=Specificity and biological distribution of coenzyme M (2-mercaptoethanesulfonic acid) |journal=J. Bacteriol. |volume=137 |issue=1 |pages=256–63 |year=1979 |pmid=104960 |pmc=218444}} {{Enzyme cofactors}}{{biochem-stub}}2. ^{{cite journal |vauthors=Taylor CD, Wolfe RS |title=Structure and methylation of coenzyme M({{chem|HSCH|2|CH|2|SO|3}}) |journal=J. Biol. Chem. |volume=249 |issue=15 |pages=4879–85 |date=10 August 1974|pmid=4367810 |url=http://www.jbc.org/cgi/reprint/249/15/4879 }} 3. ^{{cite journal | doi=10.1099/00221287-144-9-2377 | author=Thauer RK | title=Biochemistry of Methanogenesis: a Tribute to Marjory Stephenson | journal = Microbiology | year = 1998 | volume = 144 | issue = 9| pages=2377–2406 | pmid=9782487 |url=http://mic.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9782487 }} 3 : Coenzymes|Thiols|Sulfonates |
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