Shepherdson is a surname, and may refer to:

• Arunah Shepherdson Abell, American publisher
• David Shepherdson, Zookeeper
• Guy Shepherdson, Australian rugby player
• Harold Shepherdson, English football player and coach
• Jane Shepherdson, British businesswoman
• John Cedric Shepherdson, 1926–2015, logician, father of Jane and David

• Henry Salt
• Henry Salt (Egyptologist)
• Henry Salvatori
• Henry Sampson Woodfall
• Henry Samuel Boase
• Henry Samueli
• Henry Sapoznik
• Henry Sargent Codman
• Henry Sarwer-Foner
• Henry Savile (Bible translator)
• Henry Saville
• Henry Scadding
• Henry's Cat
• Henry S. Caulfield
• Henry Schacht
• Henry Schenck Tanner
• Henry Schoolcraft
• Henry Schradieck
• Henry Scoop Jackson
• Henry "Scoop" Jackson
• Henry 'Scoop' Jackson
• Henry Scott, 3rd Duke of Buccleuch
• Henry Scott Tuke
• Henry Scrope, 3rd Baron Scrope of Masham
• Henry Scrymgeour-Wedderburn, 11th Earl of Dundee