James Sykes may refer to:

• James Sykes (Continental Congress) (1725–1792), American lawyer and Continental Congressman
• James Sykes (governor) (1761–1822), American physician and Acting Governor of Delaware
• Rod Sykes (James Rodney Winter Sykes, born 1929), Canadian politician, mayor of Calgary, Alberta
• James Sykes (Canadian football) (born 1954), former CFL running back
• Jim Sykes (born 1950), journalist
• James Sykes (cricketer) (born 1992), Leicestershire County Cricket Club cricketer

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