| 词条 | David Lodge (neuroscientist) |
| 释义 |
| name = David Lodge | image = Dr_David_Lodge_FMedSci_FRS.jpg | caption = David Lodge at the Royal Society admissions day in London, July 2016 |honorific_suffix=FRS FMedSci |alma_mater = University of Bristol (PhD, DSc) |workplaces = {{Plainlist|
| thesis_title = Neuropharmacological and physiological studies on central neurones in the rat | thesis_url = http://search.proquest.com/docview/301323670/ | thesis_year = 1974 | doctoral_advisor = Tim Biscoe | academic_advisors = David Curtis | doctoral_student = | awards = Doctor of Science (2002) | website = {{URL|http://www.bris.ac.uk/synaptic/people/david-lodge/}} }}David Lodge FRS[1] is a research fellow in the Department of Physiology and Pharmacology at the University of Bristol.[1][2] EducationLodge was awarded a Bachelor of Veterinary Science degree in 1963{{where|date=April 2017}} and worked in University of Bristol as a surgeon and anaesthetist, before doing postgraduate research with Tim J. Biscoe[3] on the neuropharmacology of amino acids, he was awarded his PhD in 1974.[1][4] Research and careerDuring postdoctoral studies at the Australian National University with David Curtis, he helped establish the role of glutamate as a central neurotransmitter and characterised its actions between AMPA, N-Methyl-D-aspartic acid (NMDA) and kainate receptor subtypes. At the Royal Veterinary College, Lodge linked his interests in anaesthesia and glutamate receptors by making the key discovery that the dissociative anaesthetics, ketamine and phencyclidine,[5] selectively blocked NMDA receptors. He related NMDA receptor antagonism to psychotomimetic effects. This provided a basis for the glutamate hypothesis of schizophrenia and redirected pharmaceutical search for schizophrenia therapies. David was recruited as a director of Eli Lilly's neuroscience program, where he helped develop glutamate receptor approaches to brain diseases, resulting in clinical trials, e.g. for schizophrenia, some of which are ongoing. {{As of|2016}}, Lodge's research concerns the mechanism of action of new ‘legal highs’ and the consequences of spontaneous mutations in glutamate receptors.[1] Awards and honoursLodge was elected a Fellow of the Royal Society (FRS) in 2016[6] and a Fellow of the Academy of Medical Sciences.{{when|date=May 2016}} He was awarded a Doctor of Science degree from the University of Bristol in 2002.[7] References1. ^{{Scopus|id=7101657162}} {{Authority control}}{{FRS 2016}}{{DEFAULTSORT:Lodge, David}}{{UK-scientist-stub}}2. ^{{cite web|archiveurl=https://web.archive.org/web/20160521214654/http://www.bris.ac.uk/synaptic/people/david-lodge/|archivedate=2016-05-21|url=http://www.bris.ac.uk/synaptic/people/david-lodge/|publisher=bris.ac.uk|location=Bristol|title=Professor David Lodge, MRC Centre for Synaptic Plasticity}} 3. ^{{Cite journal | author = T. J. Biscoe, A. W. Duggan & D. Lodge | title = Effect of etorphine, morphine and diprenorphine on neurones of the cerebral cortex and spinal cord of the rat | journal = British Journal of Pharmacology | volume = 46 | issue = 2 | pages = 201–212 | year = 1972 | pmid = 4405610 | pmc = 1666335 | doi=10.1111/j.1476-5381.1972.tb06865.x}} 4. ^{{cite thesis |type=PhD|last=Lodge|first=David |date=1974|title=Neuropharmacological and physiological studies on central neurones in the rat|publisher=University of Bristol|url=http://search.proquest.com/docview/301323670/|website=proquest.com}} 5. ^{{cite journal|last1=Lodge|first1=D|last2=Mercier|first2=M S|title=Ketamine and phencyclidine: the good, the bad and the unexpected|journal=British Journal of Pharmacology|volume=172|issue=17|year=2015|pages=4254–4276|pmid=26075331|doi=10.1111/bph.13222|pmc=4556466}} 6. ^1 2 3 {{cite web|author=Anon|year=2016|url=https://royalsociety.org/people/david-lodge-12882/|title=Dr David Lodge FMedSci FRS|publisher=Royal Society|archivedate=2016-04-29|archiveurl=https://web.archive.org/web/20160429121345/https://royalsociety.org/people/david-lodge-12882/|location=London}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{cite web |url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |accessdate=2016-03-09 |deadurl=bot: unknown |archiveurl=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archivedate=September 25, 2015 |df= }}}} 7. ^{{cite thesis |type=DSc |last=Lodge|first=David |date=2002|title=Material submitted in support of candidature for Doctor of Science|publisher=University of Bristol|url=http://pmt-eu.hosted.exlibrisgroup.com/44BU_VU1:default_scope:44BU_LMS_DS000712628|website=exlibrisgroup.com|oclc=931576764}} 4 : Living people|Fellows of the Royal Society|Place of birth missing (living people)|Year of birth missing (living people) |
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