James Jefferson may refer to:

• James Jefferson (gridiron football), American and Canadian football player
• James Jefferson Webster, American politician, businessman, and farmer
• James Jefferson of The MOD Squad

• Tajikabad
• Tajikabad District
• Tajik Academy of Sciences
• Tajik-Afghan bridge at Tem-Demogan
• Tajik-Afghan Friendship Bridge
• Tajik-Afghanistan bridge at Panji Poyon
• TajikAir.TJ
• Tajik Aluminum Company
• Tajik army
• Tajik ASSR
• Tajik captives held in guantanamo
• Tajik captives held in Guantanamo
• Tajik (China)
• Tajik Cyrillic alphabet
• Tajik detainees at Guantanamo Bay
• Tajik detainees in Guantanamo
• Tajikis-tan
• Tajikistan-Afghanistan bridge at Panji Poyon
• Tajikistan-Afghanistan relations
• Tajikistan Aluminium Company
• Tajikistan Aluminum Company
• Tajikistan at the 2006 Asian Games
• Tajikistan at the 2008 Summer Olympics
• Tajikistan at the 2008 Summer Paralympics
• Tajikistan at the 2009 Asian Indoor Games